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A highly efficient group-assisted purification method for the synthesis of poly-functionalized pyrimidin-5-yl-pyrroles via one-pot four-component domino reaction

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Abstract

A highly efficient, catalyst-free group-assisted purification chemical protocol for the construction of pyrimidine containing poly-functionalized pyrroles from a four-component domino reaction of acyclic-1,3-dicarbonyls or electron deficient alkynes, aromatic amines, barbituric acid and arylglyoxal hydrates under mild reaction conditions has been developed. The prominent features of the present protocol are environmentally benign, mild reaction conditions, atom economy, no column chromatography separation, easy isolation of products and excellent yields.

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Acknowledgments

We thank CSIR, New Delhi for financial support to this work under network project. YD thanks UGC, New Delhi for the award of a senior research fellowship. We also thank the Director, CSIR-NEIST, Jorhat, for his keen interest and constant encouragement. The authors are grateful to Dr. R. K. Barua, Analytical chemistry division, CSIR-NEIST, Jorhat, Assam, India, for collecting the X-ray data.

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  1. Medicinal Chemistry Division, CSIR-North-East Institute of Science and Technology, Jorhat, 785006, Assam, India

    Yuvaraj Dommaraju & Dipak Prajapati

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  1. Yuvaraj Dommaraju
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  2. Dipak Prajapati
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Correspondence to Dipak Prajapati.

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Dommaraju, Y., Prajapati, D. A highly efficient group-assisted purification method for the synthesis of poly-functionalized pyrimidin-5-yl-pyrroles via one-pot four-component domino reaction. Mol Divers 19, 173–187 (2015). https://doi.org/10.1007/s11030-014-9547-1

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