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An efficient tandem approach for the synthesis of functionalized 2-pyridone-3-carboxylic acids using three-component reaction in aqueous media

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Abstract

Novel analogs of 2-pyridone-3-carboxylic acids 4a–l have been prepared by the three-component reaction of 3-formyl chromone, Meldrum’s acid, and primary amines in the presence of a catalytic amount of diammonium hydrogen phosphate in water. Good-to-high yields, easy work-up, and an environmentally friendly profile are the advantages of this method for the synthesis of 2-pyridone-3-carboxylic acid derivatives.

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Acknowledgments

S. B. gratefully acknowledges Alexander von Humboldt foundation for the research fellowship. We are also thanking Prof. Thomas J. J. Mueller for his invaluable comments.

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Authors and Affiliations

  1. Peptide Chemistry Research Center, K. N. Toosi University of Technology, P. O. Box 15875-4416 , Tehran, Iran

    Saber Mehrparvar, Saeed Balalaie, Mahnaz Rabbanizadeh & Elmira Ghabraie

  2. Organisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 270, 69120 , Heidelberg, Germany

    Frank Rominger

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  1. Saber Mehrparvar
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  2. Saeed Balalaie
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  3. Mahnaz Rabbanizadeh
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  4. Elmira Ghabraie
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Correspondence to Saeed Balalaie.

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Dedicated to Prof. Rolf Gleiter on the occasion of his 77th birthday.

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Mehrparvar, S., Balalaie, S., Rabbanizadeh, M. et al. An efficient tandem approach for the synthesis of functionalized 2-pyridone-3-carboxylic acids using three-component reaction in aqueous media. Mol Divers 18, 535–543 (2014). https://doi.org/10.1007/s11030-014-9522-x

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