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Catalyst-free, one-pot, three-component synthesis of 5-amino-1,3-aryl-1\(H\)-pyrazole-4-carbonitriles in green media

Molecular Diversity volume 17, pages 459–469 (2013)Cite this article

Abstract

An efficient, one-pot, three-component synthesis of various biologically important heterocyclic compounds is described via a tandem Knoevengel-cyclo condensation reaction of aromatic aldehydes, malono derivatives, and phenyl hydrazine derivatives in water and ethanol at room temperature.

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Acknowledgments

The authors thank Persian Gulf University Research Councils for the financial support of this work.

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  1. Department of Chemistry, Faculty of Sciences, Persian Gulf University, 75169 , Bushehr, Iran

    Alireza Hasaninejad & Somayeh Firoozi

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  1. Alireza Hasaninejad
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Correspondence to Alireza Hasaninejad.

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Hasaninejad, A., Firoozi, S. Catalyst-free, one-pot, three-component synthesis of 5-amino-1,3-aryl-1\(H\)-pyrazole-4-carbonitriles in green media. Mol Divers 17, 459–469 (2013). https://doi.org/10.1007/s11030-013-9445-y

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Keywords

  • Multi-component reactions
  • MCRs
  • Catalyst-free
  • Pyrazole
  • 5-Amino pyrazole
  • Green chemistry