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Targeting tuberculosis through a small focused library of 1,2,3-triazoles

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Abstract

Looking for new active molecules against Mycobacterium tuberculosis, a small focused library of 1,2,3-triazoles was efficiently prepared by click chemistry. Compounds were subsequently tested against different pathogenic and opportunistic mycobacteria including M. avium and M. tuberculosis. Two of them showed MIC at lower μg/mL concentration for M. avium and even below that for M. tuberculosis, being more potent that control drugs.

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Authors and Affiliations

  1. Instituto de Química Rosario (IQUIR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK, Rosario, Argentina

    Guillermo R. Labadie

  2. Catedra de Microbiología, Virología y Parasitología, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe 3100, S2002KTR, Rosario, Argentina

    Agustina de la Iglesia & Héctor R. Morbidoni

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  1. Guillermo R. Labadie
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  2. Agustina de la Iglesia
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  3. Héctor R. Morbidoni
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Correspondence to Guillermo R. Labadie.

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Labadie, G.R., de la Iglesia, A. & Morbidoni, H.R. Targeting tuberculosis through a small focused library of 1,2,3-triazoles. Mol Divers 15, 1017–1024 (2011). https://doi.org/10.1007/s11030-011-9319-0

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