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Discovery of a β-glucosidase inhibitor from a chemically engineered extract prepared through sulfonylation

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Abstract

A semisynthetic β-glucosidase inhibitor was identified from a chemically engineered extract prepared by reaction with benzenesulfonyl chloride. The structure includes a natural histamine portion and a benzenesulfonyl portion introduced during the diversification step.

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Authors and Affiliations

  1. Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000, Rosario, Argentina

    Mario O. Salazar, Andrea M. Escalante & Ricardo L. E. Furlan

  2. Departamento de Química, Escuela de Ciencias Agrarias, Naturales y Ambientales, Universidad Nacional del Noroeste de la Provincia de Buenos Aires, Monteagudo 2772, 2700, Pergamino, Argentina

    Oscar Micheloni

Authors
  1. Mario O. Salazar
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  2. Oscar Micheloni
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  3. Andrea M. Escalante
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  4. Ricardo L. E. Furlan
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Correspondence to Ricardo L. E. Furlan.

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Salazar, M.O., Micheloni, O., Escalante, A.M. et al. Discovery of a β-glucosidase inhibitor from a chemically engineered extract prepared through sulfonylation. Mol Divers 15, 713–719 (2011). https://doi.org/10.1007/s11030-010-9301-2

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  • DOI: https://doi.org/10.1007/s11030-010-9301-2

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