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Highly efficient and catalyst-free synthesis of substituted thioureas in water

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Abstract

A highly efficient and catalyst-free method for the synthesis of substituted thiourea derivatives is presented. The synthesis is performed through the reaction of thiazolidine-2-thiones with various amines in water. A sound number of thioureas with both unsymmetrical and symmetrical architectures have been obtained in good to excellent yields.

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Authors and Affiliations

  1. Department of Chemistry, Zhejiang University, Hangzhou, 310027, People’s Republic of China

    Shi-Feng Gan, Jie-Ping Wan, Yuan-Jiang Pan & Cui-Rong Sun

  2. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi, 330022, People’s Republic of China

    Jie-Ping Wan

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  1. Shi-Feng Gan
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  2. Jie-Ping Wan
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  3. Yuan-Jiang Pan
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  4. Cui-Rong Sun
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Correspondence to Cui-Rong Sun.

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Gan, SF., Wan, JP., Pan, YJ. et al. Highly efficient and catalyst-free synthesis of substituted thioureas in water. Mol Divers 15, 809–815 (2011). https://doi.org/10.1007/s11030-010-9298-6

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  • DOI: https://doi.org/10.1007/s11030-010-9298-6

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