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Diversity-oriented, one-pot, multi-component synthesis of substituted uracil derivatives

Molecular Diversity volume 15, pages 263–267 (2011)Cite this article

Abstract

With the emergence of high throughput screening of bioactive molecules, there is constant need for the development of new strategies for diversity-oriented synthesis. We describe here a novel one-pot multicomponent reaction for the synthesis of uracil derivatives using easily available starting materials. This new synthetic strategy provides easy access to diverse uracil derivatives in moderate to good yields.

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Affiliations

  1. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N. Parekh Marg, Matunga, Mumbai, 400019, India

    Yogesh Y. Pedgaonkar & Mariam S. Degani

  2. Spring Bank Pharmaceuticals, Inc., Milford, MA, 01757, USA

    Radhakrishnan P. Iyer

Authors
  1. Yogesh Y. Pedgaonkar
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  2. Mariam S. Degani
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  3. Radhakrishnan P. Iyer
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Corresponding author

Correspondence to Mariam S. Degani.

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Pedgaonkar, Y.Y., Degani, M.S. & Iyer, R.P. Diversity-oriented, one-pot, multi-component synthesis of substituted uracil derivatives. Mol Divers 15, 263–267 (2011). https://doi.org/10.1007/s11030-010-9266-1

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  • DOI: https://doi.org/10.1007/s11030-010-9266-1

Keywords

  • Multicomponent reaction
  • Carbonylation
  • Cyclization
  • 5-cyanouracil
  • Triphosgene
  • MCR