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One-pot multicomponent synthesis of two novel thiolactone scaffolds

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Abstract

We designed two novel thiolactone scaffolds. Both scaffolds can be accessed by a convergent Ugi multicomponent reaction (MCR) and are, thus, amenable to library synthesis. Design, stereoselectivity, structures, full experimental details, and virtual libraries will be reported.

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Abbreviations

MCR:

Multicomponent reaction

HTMP:

Homocysteine thiolactone-induced protein modification

HTL:

Homocysteine thiolactone

UDC:

Ugi–deprotection–cyclization sequences

IMCR:

Isocyanide based MCR

FDA:

Food and drug administration

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Authors and Affiliations

  1. Department of Pharmacy, University of Pittsburgh, Pittsburgh, PA, 15261, USA

    B. Beck, S. Srivastava, K. Khoury & Alexander Dömling

  2. Technical University Munich, Munich, Germany

    E. Herdtweck

Authors
  1. B. Beck
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  2. S. Srivastava
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  3. K. Khoury
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  4. E. Herdtweck
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  5. Alexander Dömling
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Correspondence to Alexander Dömling.

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First two authors contributed equally.

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Beck, B., Srivastava, S., Khoury, K. et al. One-pot multicomponent synthesis of two novel thiolactone scaffolds. Mol Divers 14, 479–491 (2010). https://doi.org/10.1007/s11030-010-9249-2

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