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Facile and efficient synthesis of functionalized iminothiopyran and isothiochromen via one-pot multicomponent reactions

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Abstract

An efficient synthesis of 6H-6-iminothiopyran-2,3-dicarboxylate and 1H-isothiochromene-3,4-dicarboxylate derivatives via one-pot reactions between acetylenic esters, aryl isothiocyanates and enaminones in dichloromethane at room temperature is described. The mild reaction condition, high yields and the new products are advantages of our method.

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Authors and Affiliations

  1. Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran

    Hosein Hamadi

  2. Department of Chemistry, Zanjan University, P.O. Box 45195-313, Zanjan, Iran

    Mehdi Khoobi

  3. Chemistry Department, Islamic Azad University, P.O. Box 163, Qaemshahr Branch, Mazandaran, Iran

    Zinatossadat Hossaini

  4. Department of Chemistry, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran

    Abbas Shafiee

Authors
  1. Hosein Hamadi
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  2. Mehdi Khoobi
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  3. Zinatossadat Hossaini
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  4. Abbas Shafiee
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Corresponding author

Correspondence to Abbas Shafiee.

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Hamadi, H., Khoobi, M., Hossaini, Z. et al. Facile and efficient synthesis of functionalized iminothiopyran and isothiochromen via one-pot multicomponent reactions. Mol Divers 15, 35–40 (2011). https://doi.org/10.1007/s11030-010-9230-0

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  • DOI: https://doi.org/10.1007/s11030-010-9230-0

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