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[Hmim]TFA catalyzed multicomponent reaction: direct, mild, and efficient procedure for the synthesis of 1,2-dihydroquinazoline derivatives

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Abstract

4-Substituted-spiro-1,2-dihydroquinazolines and related compounds were synthesized by direct reaction of 2-aminobenzophenones, isatin, or 1,2-diketone derivatives and ammonium acetate in the presence of dual role catalyst-solvent ionic liquid, [Hmim]TFA. Excellent conversion of starting materials was achieved to the desired 1,2-dihydroquinazoline products.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Shahid Beheshti University, G. C., Evin, Tehran, 1983963113, Iran

    Minoo Dabiri & Mahboobeh Bahramnejad

  2. Department of Marine Biology, Faculty of Biological Sciences, Shahid Beheshti University, G. C., Evin, Tehran, Iran

    Sahareh Bashiribod

Authors
  1. Minoo Dabiri
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  2. Mahboobeh Bahramnejad
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  3. Sahareh Bashiribod
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Correspondence to Minoo Dabiri.

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Dabiri, M., Bahramnejad, M. & Bashiribod, S. [Hmim]TFA catalyzed multicomponent reaction: direct, mild, and efficient procedure for the synthesis of 1,2-dihydroquinazoline derivatives. Mol Divers 14, 507–512 (2010). https://doi.org/10.1007/s11030-009-9219-8

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  • DOI: https://doi.org/10.1007/s11030-009-9219-8

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