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Efficiency in chemistry: from hydrogen autotransfer to multicomponent catalysis

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Abstract

A hydrogen autotransfer reaction has been applied to the α-alkylation of ketones, with primary alcohols as the electrophilic component, either under homogeneous (using a Ru complex as catalyst) or under heterogeneous (using Ni nanoparticles) conditions. This process is both very efficient (concerning atom economy) and ecologically friendly (water as the only by-product generated). On the other hand, three multicomponent reactions, namely, the Strecker reaction (without any catalyst), the aza-Sakurai process (catalyzed by ferrite), and the addition of in situ generated Zn enolates to chiral sulfinylimines (catalyzed by Cu), have proven to be very efficient in the generation of a diversity of polyfunctionalized molecules.

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Authors and Affiliations

  1. Instituto de Síntesis Orgánica and Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Alicante, Apdo. 99, 03080, Alicante, Spain

    Francisco Alonso, Francisco Foubelo, José C. González-Gómez, Ricardo Martínez, Diego J. Ramón, Paola Riente & Miguel Yus

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  1. Francisco Alonso
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  2. Francisco Foubelo
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  3. José C. González-Gómez
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  4. Ricardo Martínez
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  5. Diego J. Ramón
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  6. Paola Riente
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  7. Miguel Yus
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Correspondence to Miguel Yus.

Additional information

This account is based on a lecture delivered by one of the authors (M.Y.) at the IV International Conference on ‘Multi-Component Reactions and Related Chemistry’, Ekaterinburg (Russia), May 24–28.

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Alonso, F., Foubelo, F., González-Gómez, J.C. et al. Efficiency in chemistry: from hydrogen autotransfer to multicomponent catalysis. Mol Divers 14, 411–424 (2010). https://doi.org/10.1007/s11030-009-9195-z

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  • DOI: https://doi.org/10.1007/s11030-009-9195-z

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