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Electrocatalytic multicomponent assembling of isatins, 3-methyl-2-pyrazolin-5-ones and malononitrile: facile and convenient way to functionalized spirocyclic [indole-3,4′-pyrano[2,3-c]pyrazole] system

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Abstract

Electrochemically induced catalytic multicomponent transformation of isatins, 3-methyl-2-pyrazolin-5-ones and malononitrile in ethanol in an undivided cell in the presence of sodium bromide as an electrolyte results in the formation of spirooxindoles with fused functionalized pyrano[2,3-c]pyrazole system in 78–99} yields. The developed efficient electrocatalytic approach to medicinally relevant spirocyclic [indole-3,4′-pyrano[2,3-c]pyrazoles] is beneficial from the viewpoint of diversity-oriented large-scale processes and represents a novel example of facile environmentally benign synthetic concept for electrocatalytic multicomponent reaction strategy.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Leninsky Prospect 47, 119991, Moscow, Russia

    Michail N. Elinson, Alexander S. Dorofeev, Fedor M. Miloserdov & Gennady I. Nikishin

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  1. Michail N. Elinson
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  2. Alexander S. Dorofeev
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  3. Fedor M. Miloserdov
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  4. Gennady I. Nikishin
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Correspondence to Michail N. Elinson.

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Elinson, M.N., Dorofeev, A.S., Miloserdov, F.M. et al. Electrocatalytic multicomponent assembling of isatins, 3-methyl-2-pyrazolin-5-ones and malononitrile: facile and convenient way to functionalized spirocyclic [indole-3,4′-pyrano[2,3-c]pyrazole] system. Mol Divers 13, 47–52 (2009). https://doi.org/10.1007/s11030-008-9100-1

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  • DOI: https://doi.org/10.1007/s11030-008-9100-1

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