Molecular Diversity

, Volume 13, Issue 1, pp 63–67 | Cite as

A novel synthesis of highly substituted imidazo[1,5-a]pyrazine derivatives by 3-CR/2-CR sequence

  • Ahmad ShaabaniEmail author
  • Ali Maleki
  • Hamid Mofakham
Short Communication


By combining a three-component reaction of 2, 3-diaminomaleonitrile, ketones and isocyanides with a subsequent reaction of 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives obtained from isocyanide-based three-component reaction with various alkyl and aryl isocyanates or isothiocyanates can be assembled a new class of highly substituted imidazo[1,5-a]pyrazine derivatives.


Imidazo[1,5-a]pyrazine Isocyanide Isocyanate 2,3-Diaminomaleonitrile Multicomponent reaction 


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  1. 1.Department of ChemistryShahid Beheshti UniversityTehranIran

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