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Diammonium hydrogen phosphate as a versatile and efficient catalyst for the one-pot synthesis of pyrano[2,3-d]pyrimidinone derivatives in aqueous media

Molecular Diversity volume 12, pages 85–91 (2008)Cite this article

Abstract

Diammonium hydrogen phosphate, (NH4)2HPO4, was used as a catalyst for one-pot, three-component condensation reactions consisting of aromatic aldehydes, malononitrile and barbituric/thiobarbituric acid in aqueous ethanol at room temperature. This method has the advantages of a simple operation, mild reaction conditions, high yields, by using a less toxic and low cost chemical as a catalyst.

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Authors and Affiliations

  1. Peptide Chemistry Research Group, K.N. Toosi University of Technology, P.O. Box 15785-4416, Tehran, Iran

    Saeed Balalaie & Ali Mohammad Amani

  2. School of Chemistry College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran

    Shahrzad Abdolmohammadi

  3. Department of Chemistry, Tarbiat Modarres University, P.O. Box 14115-175, Tehran, Iran

    Hamid Reza Bijanzadeh

Authors
  1. Saeed Balalaie
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  2. Shahrzad Abdolmohammadi
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  3. Hamid Reza Bijanzadeh
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  4. Ali Mohammad Amani
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Correspondence to Saeed Balalaie.

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Balalaie, S., Abdolmohammadi, S., Bijanzadeh, H.R. et al. Diammonium hydrogen phosphate as a versatile and efficient catalyst for the one-pot synthesis of pyrano[2,3-d]pyrimidinone derivatives in aqueous media. Mol Divers 12, 85–91 (2008). https://doi.org/10.1007/s11030-008-9079-7

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  • DOI: https://doi.org/10.1007/s11030-008-9079-7

Keywords

  • Aqueous media
  • Diammonium hydrogen phosphate (DAHP)
  • Pyrano[2, 3-d]pyrimidinone
  • Domino Knoevenagel–Michael addition
  • Multicomponent reaction (MCR)