Three-Component Synthesis of Dialkyl 2-(Alkylimino-Methylene)3- (2,2,5-Trimethyl-4,6-Dioxo-1,3-Dioxan-5-Yl)-Succinates

Summary

The adduct produced in the reaction between alkyl isocyanides and dialkyl acetylenedicarboxylates was trapped by 2,2,5-trimethyl-1,3-dioxane-4,6-dione (methyl Meldrum's acid), to afford highly functionalized ketenimines in good yields.

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Correspondence to Issa Yavari.

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Yavari, I., Zare, H. & Mohtat, B. Three-Component Synthesis of Dialkyl 2-(Alkylimino-Methylene)3- (2,2,5-Trimethyl-4,6-Dioxo-1,3-Dioxan-5-Yl)-Succinates. Mol Divers 10, 247–250 (2006). https://doi.org/10.1007/s11030-005-9010-4

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Key words

  • methyl Meldrum's acid
  • multi-component reaction
  • acetylenic ester
  • isocyanide
  • ketenimine