Skip to main content

Advertisement

Log in

Between hype and hope: What is really at stake with personalized medicine?

  • Scientific Contribution
  • Published:
Medicine, Health Care and Philosophy Aims and scope Submit manuscript

Abstract

Over the last decade, personalized medicine has become a buzz word, which covers a broad spectrum of meanings and generates many different opinions. The purpose of this article is to achieve a better understanding of the reasons why personalized medicine gives rise to such conflicting opinions. We show that a major issue of personalized medicine is the gap existing between its claims and its reality. We then present and analyze different possible reasons for this gap. We propose an hypothesis inspired by the Windelband’s distinction between nomothetic and idiographic methodology. We argue that the fuzzy situation of personalized medicine results from a mix between idiographic claims and nomothetic methodological procedures. Hence we suggest that the current quandary about personalized medicine cannot be solved without getting involved in a discussion about the complex epistemological and methodological status of medicine. To conclude, we show that the Gadamer’s view of medicine as a dialogical process can be fruitfully used and reveals that personalization is not a theoretical task, but a practical one, which takes place within the clinical encounter.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Árnason, Vilhjálmur. 2012. The personal is political: Ethics and personalized medicine. Ethical Perspectives 19(1): 103–122.

    Google Scholar 

  • Bensaude-Vincent, Bernadette. 2014. The politics of buzzwords at the interface of technoscience, market and society: The case of ‘public engagement in science’. Public Understanding of Science 23(3): 238–253.

    Article  Google Scholar 

  • Buzzoni, Marco. 2003. Medicine as a human science between the singularity of the patient and technical scientific reproducibility. Poiesis & Praxis 1(3): 171–184.

    Article  Google Scholar 

  • Chadwick, Ruth. 2014. The ethics of personalized medicine: A philosopher’s perspective. Personalized Medicine 11(1): 5–6.

    Article  Google Scholar 

  • Dion-Labrie, Marianne, Marie-Chantal Fortin, Marie-Josée Hébert, and Hubert Doucet. 2008. Réflexions éthiques sur la médecine personnalisée: l’alliance de la science et de la médecine enfin réalisée? Revista Colombiana de Bioética 3(2): 33–56.

    Google Scholar 

  • Fleck, Leonard M. 2010. Personalized medicine’s ragged edge. The Hastings Center Report 40(5): 16–18.

    Article  Google Scholar 

  • Gadamer, Hans-Georg. 1996. The enigma of health: the art of healing in a scientific age. Stanford: Stanford University Press.

    Google Scholar 

  • Gadamer, Hans-Georg. 2004. Truth and method. London, New York: Continuum.

    Google Scholar 

  • Green, Eric D., Mark S. Guyer, and The National Human Genome Research Institute. 2011. Charting a course for genomic medicine from base pairs to bedside. Nature 470(7333): 204–213.

    Article  Google Scholar 

  • Hedgecoe, Adam. 2004. The politics of personalised medicine: Pharmacogenetics in the clinic. Cambridge: Cambridge University Press.

    Book  Google Scholar 

  • Heßling, Arndt, and Silke Schicktanz. 2012. What German experts expect from individualized medicine: Problems of uncertainty and future complication in physician–patient interaction. Clinical Ethics 7(2): 86–93.

    Article  Google Scholar 

  • Jain, Kewal. 2015. Textbook of personalized medicine, 2nd ed. New York: Springer.

    Google Scholar 

  • Johnson, Julie A. 2008. Ethnic differences in cardiovascular drug response potential contribution of pharmacogenetics. Circulation 118(13): 1383–1393.

    Article  Google Scholar 

  • Kalow, Werner. 2001. Interethnic differences in drug response. Drugs and the Pharmaceutical Sciences 113: 109–134.

    Google Scholar 

  • Kuhn, Thomas Samuel. 1970. The structure of scientific revolutions. Chicago and London: The University of Chicago Press.

    Google Scholar 

  • Langanke, Martin, Wolfgang Lieb, Pia Erdmann, Marcus Dörr, Tobias Fischer, Heyo K. Kroemer, Steffen Flessa and Heinrich Assel. 2015. The Meaning of “Individualized Medicine”: A Terminological Adjustment of a Perplexing Term. In Individualized Medicine. Ethical, economical and historical perspectives, ed. Tobias Fischer, Martin Langanke, Paul Marschall and Susanne Michl, 11–28. Heidelberg, New York Dordrecht London: Springer.

  • Michl, Susanne. 2015. Inventing traditions, raising expectations. Recent debates on “Personalized Medicine”. In Individualized medicine. Ethical, economical and historical perspectives, ed. Tobias Fischer, Martin Langanke, Paul Marschall, and Susanne Michl, 45–60. New York: Springer.

    Google Scholar 

  • Nelkin, Dorothy. 1994. Promotional metaphors and their popular appeal. Public Understanding of Science 3(1): 25–31.

    Article  Google Scholar 

  • Offit, Kenneth. 2011. Personalized medicine: New genomics, old lessons. Human Genetics 130(1): 3–14.

    Article  Google Scholar 

  • Papavassiliou, Athanasios G. 2010. Molecular medicine: Prometheus unbound. BioEssays 32(6): 453. doi:10.1002/bies.201090017.

    Article  Google Scholar 

  • Pokorska-Bocci, Anna, Alison Stewart, Gurdeep S. Sagoo, Alison Hall, Mark Kroese, and Hilary Burton. 2014. “Personalized medicine”: What’s in a name? Personalized Medicine 11(2): 197–210.

    Article  Google Scholar 

  • Schleidgen, Sebastian, Corinna Klingler, Teresa Bertram, Wolf H. Rogowski, and Georg Marckmann. 2013. What is personalized medicine: Sharpening a vague term based on a systematic literature review. BMC Medical Ethics 14(1): 55.

    Article  Google Scholar 

  • Schleidgen, Sebastian, and Georg Marckmann. 2013. Alter Wein in neuen Schläuchen? Ethische Implikationen der Individualisierten Medizin. Ethik in der Medizin 25(3): 223–231.

    Article  Google Scholar 

  • Smart, Andrew, Paul Martin, and Michael Parker. 2004. Tailored medicine: Whom will it fit? The ethics of patient and disease stratification. Bioethics 18: 322–343.

    Article  Google Scholar 

  • Steele, Fintan R. 2009. Personalized medicine: something old, something new. Personalized Medicine 6: 1–5.

    Article  Google Scholar 

  • Svenaeus, Fredrik. 2000a. Hermeneutics of clinical practice: The question of textuality. Theoretical Medicine and Bioethics 21(2): 171–189.

    Article  Google Scholar 

  • Svenaeus, Fredrik. 2000b. The hermeneutics of medicine and the phenomenology of health: Steps towards a philosophy of medical practice. Dordrecht, Boston, London: Kluwer Academic Publishers.

    Book  Google Scholar 

  • Svenaeus, Fredrik. 2003. Hermeneutics of medicine in the wake of Gadamer: The issue of phronesis. Theoretical Medicine and Bioethics 24(5): 407–431.

    Article  Google Scholar 

  • Sykiotis, Gerasimos P., George D. Kalliolias, and Athanasios G. Papavassiliou. 2005. Pharmacogenetic principles in the Hippocratic writings. The Journal of Clinical Pharmacology 45(11): 1218–1220.

    Article  Google Scholar 

  • Tutton, Richard. 2012. Personalizing medicine: Futures present and past. Social Science and Medicine 75(10): 1721–1728.

    Article  Google Scholar 

  • van Lente, Harro, and Arie Rip. 1998. The rise of membrane technology from Rhetorics to social reality. Social Studies of Science 28(2): 221–254.

    Article  Google Scholar 

  • Vollmann, Jochen. 2013. Persönlicher-besser-kostengünstiger? Kritische medizinethische Anfragen an die „personalisierte Medizin. Ethik in der Medizin 3(25): 233–241.

    Article  Google Scholar 

  • What Happened to Personalized Medicine?. 2012. Nature Biotechnology 30 (1): 1–1.

  • Windelband, Wilhelm. 1980. History and natural science. History and Theory 19(2): 169–185.

    Article  Google Scholar 

  • Yurkiewicz, Shara. 2010. The prospects for personalized medicine. The Hastings Center Report 40(5): 14–16.

    Article  Google Scholar 

Download references

Acknowledgments

The author would like to thank Pascaline Rocher for her help in editing the initial manuscript.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Camille Abettan.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Abettan, C. Between hype and hope: What is really at stake with personalized medicine?. Med Health Care and Philos 19, 423–430 (2016). https://doi.org/10.1007/s11019-016-9697-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11019-016-9697-2

Keywords

Navigation