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Estimation of Measurement Uncertainties in Laboratory Medicine

  • MEDICAL AND BIOLOGICAL MEASUREMENTS
  • Published:
Measurement Techniques Aims and scope

This article discusses the issues on the veracity of measurement results in laboratory diagnostics, which are used as a basis in making medical decisions. For a correct diagnosis establishment, especially if the measurement results are close to the reference values of the parameters being determined, the accuracy and/or uncertainties of measurement results should be evaluated. The work considers the practical application of the document ISO/TS 20914:2019 "Medical laboratories ― Practical guidance for the estimation of measurement uncertainty," which uses the methodology of the Guide to the Expression of. Uncertainty in Measurement and outlines a practical approach to estimating uncertainties based on information available in a laboratory. This article presents an example of estimating measurement uncertainties performed in a medical laboratory. Particular attention was paid to the assessment of the measurement precision, i.e., type A uncertainty. The data available in the laboratory were analyzed, and the compliance of the obtained measurement results with current requirements was assessed. The implementation of ISO/TS 20914:2019 in activities of medical laboratories enables to evaluate the uncertainties of measurements conducted in the laboratory and the factors that make maximum contribution to measurement uncertainties.

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Authors and Affiliations

  1. D. I. Mendeleev Institute for Metrology (VNIIM), St. Petersburg, Russia

    A. G. Chunovkina, A. A. Tumilovich, A. V. Stepanov & M. S. Vonsky

  2. The Nikiforov Russian Center for Emergency and Radiation Medicine (NRCERM, EMERCOM of Russia), St. Petersburg, Russia

    N. A. Kovyazina & N. A. Alkhutova

  3. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

    V. L. Emanuel

Authors
  1. A. G. Chunovkina
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  2. A. A. Tumilovich
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  3. A. V. Stepanov
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  4. M. S. Vonsky
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  5. N. A. Kovyazina
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  6. N. A. Alkhutova
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  7. V. L. Emanuel
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Corresponding author

Correspondence to A. G. Chunovkina.

Additional information

Translated from Izmeritel'naya Tekhnika, No. 7, pp. 69–74, July, 2022.

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Chunovkina, A.G., Tumilovich, A.A., Stepanov, A.V. et al. Estimation of Measurement Uncertainties in Laboratory Medicine. Meas Tech 65, 536–542 (2022). https://doi.org/10.1007/s11018-023-02117-9

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  • DOI: https://doi.org/10.1007/s11018-023-02117-9

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