We have estimated the nonuniformity of the dose distribution along the body of a patient using in vivo dosimetry by semiconductor detectors with total therapeutic irradiation of cancer patients before bone marrow transplantation. The method of in vivo dosimetry was developed and used at the Blokhin Oncology Center since 2007. Based on the results of the investigation of 35 patients, we determined a mean nonuniformity of 10–15% of the dose distribution along the body of the patient, which conforms to international recommendations. We show a linear dependence of the accumulated dose on the mass of the patient.
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A. V. Sumin et al., “Verification of the operation of a scintillation, multichannel clinical MKD-04 dosimeter in a collimated, gamma-radiation beam from a 60Co source,” Med. Fizika, No. 3 (75), 24–33 (2017).
G. Rikner, Silicon Diodes as Detectors in Relative Dosimetry of Photon, Electron and Proton Radiation Fields, Uppsala Univ., Uppsala (1983).
J. Van Dam and G. Marinello, “Methods for in vivo dosimetry in external radiotherapy,” ESTRO Booklet No. 1, Scribd Inc., Brussels (Belgium), (1994), pp. 12–35.
D. Huyskens et al., “Practical guidelines for the implementation of in vivo dosimetry with diodes in external radiotherapy with photon beams (entrance dose),” ESTRO Booklet No. 5, Scribd Inc., Brussels (Belgium), (2001), pp. 4–12.
T. A. Krylova, O. S. Talariko, and I. M. Lebedenko, “Use of semiconductor detectors for in vivo dosimetry for total body radiation,” Med. Fizika, No. 1 (73), 25–29 (2017).
A. J. Olch et al., “Dosimetric effects caused by couch tops and immobilization devices: A report of AAPM Task Group 176,” Med. Physics, 41, Iss. 6, Pt. 1, 2–30 (2014).
K. N. Melkova et al., “Total irradiation of the body of a person for bone-marrow transplantation,” Klin. Onkogematol., Fund. Issl. Klin. Prakt., 5, No. 2, 96–114 (2012).
I. M. Lebedenko et al., “Carrying out total irradiation of a patient before bone-marrow transplantation,” Rad. Onkol. Yad. Med., No. 2, 30–36 (2012).
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Translated from Izmeritel’naya Tekhnika, No. 8, pp. 69–71, August, 2018.
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Lebedenko, I.M., Khromov, S.S., Neudakhin, D.V. et al. Estimate of Nonuniformity of Dose Distribution in Regime of Total Therapeutic Irradiation with In Vivo Dosimetry Using Semiconductor Detectors. Meas Tech 61, 836–839 (2018). https://doi.org/10.1007/s11018-018-1511-5
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DOI: https://doi.org/10.1007/s11018-018-1511-5