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Ensuring the Reliability of Measurements of the Radiochemical Purity of Radiopharmaceutical Samples by Scanning Thin-Layer Chromatograms

  • Physicochemical Measurements
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Measurement Techniques Aims and scope

The relation between the accuracy of measurements of the radiochemical purity of a radiopharmaceutical sample by scanning the bands of a thin-layer chromatograph and the scanning parameters is demonstrated. The components of the measurement error are determined. The results of work to produce a metrological and apparatus backup for this method, in the form of the Gammaskan-01A scanning instrument, are presented.

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References

  1. State Pharmacopoeia of the Russian Federation, 12th ed., Moscow (2007), Pt. 1.

  2. Federal Law No. 102-FZ, Ensuring Uniformity of Measurements, June 26, 2008.

  3. M. A. Bogorodskaya and G. E. Kodina, The Chemical Technology of Radiopharmaceutical Preparations [in Russian], Moscow (2010).

  4. GOST 28365–89, Reagents. The Paper Method of Chromatography.

  5. GOST 28365–89, Reagents. The Thin-Layer Method of Chromatography.

  6. RMG 29–99, GSI. Metrology. Basic Terms and Definitions.

  7. GOST 8.009–84, GSI. Standardized Metrological Characteristics of Measuring Instruments.

  8. Guid to the Expression of Uncertainty in Measurement, VNIIM, St. Petersburg (1999).

  9. RMG 91–2009, GSI. The Combined Use of the Ideas of “Measurement Error” and “Measurement Uncertainty.” General Principles.

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Authors and Affiliations

  1. Amplituda Scientific-Technical Center, Mendeleevo, Russia

    S. Yu. Antropov, N. S. Bozhko & S. V. Korostin

Authors
  1. S. Yu. Antropov
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  2. N. S. Bozhko
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  3. S. V. Korostin
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Corresponding author

Correspondence to S. Yu. Antropov.

Additional information

Translated from Izmeritel’naya Tekhnika, No. 10, pp. 60–65, October, 2013.

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Antropov, S.Y., Bozhko, N.S. & Korostin, S.V. Ensuring the Reliability of Measurements of the Radiochemical Purity of Radiopharmaceutical Samples by Scanning Thin-Layer Chromatograms. Meas Tech 56, 1181–1189 (2014). https://doi.org/10.1007/s11018-014-0352-0

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  • DOI: https://doi.org/10.1007/s11018-014-0352-0

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