Abstract
Alzheimer's disease (AD) lacks effective clinical treatments. As the disease progresses, the cerebral glucose hypometabolism that appears in the preclinical phase of AD gradually worsens, leading to increasingly severe brain energy disorders. This review analyzes the brain energy deficit in AD and its etiology, brain energy rescue strategies based on ketone intervention, the effects and mechanisms of IF, the differences in efficacy between IF and ketogenic diet and the duality of IF. The evidence suggests that brain energy deficits lead to the development and progression of AD pathology. IF, which improves brain energy impairments by promoting ketone metabolism, thus has good therapeutic potential for AD.
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This work was supported by the Applied Basic Research Program of Shanxi Province of China, No. 20210302123306 (to ZJW); National Natural Science Foundation of China, No. 82171428 (to HYC); and Research Project supported by Shanxi Scholarship Council of China, No. 2022–115 (to HYC).
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Ye, Y.C., Chai, SF., Li, XR. et al. Intermittent fasting and Alzheimer's disease—Targeting ketone bodies as a potential strategy for brain energy rescue. Metab Brain Dis 39, 129–146 (2024). https://doi.org/10.1007/s11011-023-01288-2
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DOI: https://doi.org/10.1007/s11011-023-01288-2