Abstract
Traumatic brain injury (TBI) leads to post-traumatic epilepsy (PTE); hence, both TBI and PTE share various similar molecular mechanisms. MicroRNA (miRNA) is a small noncoding RNA that acts as a gene-silencing molecule. Notably, the dysregulation of miRNAs in various neurological diseases, including TBI and epilepsy, has been reported in several studies. However, studies on commonly dysregulated miRNAs and the regulation of shared pathways in both TBI and epilepsy that can identify potential biomarkers of PTE are still lacking. This systematic review covers the peer-review publications of TBI and database studies of epilepsy-dysregulated miRNAs of clinical studies. For TBI, 290 research articles were identified after screening, and 12 provided data for dysregulated miRNAs in humans. The compiled data suggest that 85 and 222 miRNAs are consecutively dysregulated in TBI and epilepsy. In both, 10 miRNAs were found to be commonly dysregulated, implying that they are potentially dysregulated miRNAs for PTE. Furthermore, the targets and involvement of each putative miRNA in different pathways were identified and evaluated. Additionally, clusters of predicted miRNAs were analyzed. Each miRNA’s regulatory role was linked with apoptosis, inflammation, and cell cycle regulation pathways. Hence, these findings provide insight for future diagnostic biomarkers.
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Data availability
The datasets presented in this study are available in online EpimiRBase (https://www.epimirbase.eu/) and Pubmed (https://pubmed.ncbi.nlm.nih.gov/) repository. The names of the repositories can be found in the article/supplementary material.
References
Adelöw C, Ahlbom A, Feychting M et al (2006) Epilepsy as a risk factor for cancer. J Neurol Neurosurg Psychiatry 77(6):784–6. https://doi.org/10.1136/jnnp.2005.083931
An N, Zhao W, Liu Y et al (2016) Elevated serum miR-106b and miR-146a in patients with focal and generalized epilepsy. Epilepsy Res 127:311–316. https://doi.org/10.1016/j.eplepsyres.2016.09.019
Atif H, Hicks SD (2019) A review of microRNA biomarkers in traumatic brain injury. J Exp Neurosci 13:117906951983228. https://doi.org/10.1177/1179069519832286
Au AK, Aneja RK, Bell MJ et al (2012) Cerebrospinal fluid levels of high-mobility group box 1 and cytochrome C predict outcome after pediatric traumatic brain injury. J Neurotrauma 29:2013–2021. https://doi.org/10.1089/neu.2011.2171
Backes C, Kehl T, Stöckel D et al (2017) MiRPathDB: a new dictionary on microRNAs and target pathways. Nucleic Acids Res 45:D90–D96. https://doi.org/10.1093/nar/gkw926
Barreiro-Iglesias A (2021) Role of cyclooxygenases and prostaglandins in adult brain neurogenesis. Prostaglandins Other Lipid Mediat 152:106498. https://doi.org/10.1016/J.PROSTAGLANDINS.2020.106498
Beghi E (2020) The epidemiology of epilepsy. Neuroepidemiology 54:185–191. https://doi.org/10.1159/000503831
Beghi E (2003) Overview of studies to prevent post-traumatic epilepsy. Epilepsia 44:21–26. https://doi.org/10.1046/j.1528-1157.44.s10.1.x
Bonneau E, Neveu B, Kostantin E et al (2019) How close are miRNAs from clinical practice? A perspective on the diagnostic and therapeutic market. Electron J Int Fed Clin Chem Lab Med 30:114–127
Cattani AA, Allene C, Seifert V et al (2016) Involvement of microRNAs in epileptogenesis. Epilepsia 57:1015–1026. https://doi.org/10.1111/epi.13404
Çevik S, Özgenç MM, Güneyk A et al (2019) NRGN, S100B and GFAP levels are significantly increased in patients with structural lesions resulting from mild traumatic brain injuries. Clin Neurol Neurosurg 183:105380. https://doi.org/10.1016/j.clineuro.2019.105380
Chamani E, Sargolzaei J, Tavakoli T, Rezaei Z (2019) MicroRNAs: novel markers in diagnostics and therapeutics of celiac disease. DNA Cell Biol 38:708–717. https://doi.org/10.1089/dna.2018.4561
Chan WC, Ho MR, Li SC et al (2012) MetaMirClust: Discovery of miRNA cluster patterns using a data-mining approach. Genomics 100:141–148. https://doi.org/10.1016/j.ygeno.2012.06.007
Chang BS, Lowenstein DH (2003) Epilepsy. N Engl J Med 349:1257–1266. https://doi.org/10.1056/NEJMra022308
Chen D, Wang X, Huang J et al (2020a) CDKN1B mediates apoptosis of neuronal cells and inflammation induced by oxyhemoglobin via miR-502-5p after subarachnoid hemorrhage. J Mol Neurosci 70:1073–1080. https://doi.org/10.1007/s12031-020-01512-z
Chen L, Wang Y, Chen Z (2020b) Adult neurogenesis in epileptogenesis: an update for preclinical finding and potential clinical translation. Curr Neuropharmacol 18(6):464–484. https://doi.org/10.2174/1570159X17666191118142314
Chen Q, Gao Y, Yu Q et al (2020c) MiR-30a-3p inhibits the proliferation of liver cancer cells by targeting DNMT3a through the PI3K/AKT signaling pathway. Oncol Lett 19:606–614. https://doi.org/10.3892/ol.2019.11179
Chen S, Li F, Chai H et al (2015) miR-502 inhibits cell proliferation and tumor growth in hepatocellular carcinoma through suppressing phosphoinositide 3-kinase catalytic subunit gamma. Biochem Biophys Res Commun 464:500–505. https://doi.org/10.1016/j.bbrc.2015.06.168
Chen S, Wang L, Yao B et al (2019) miR-1307–3p promotes tumor growth and metastasis of hepatocellular carcinoma by repressing DAB2 interacting protein. Biomed Pharmacother 117:109055. https://doi.org/10.1016/j.biopha.2019.109055
Coolen M, Thieffry D, Drivenes Ø et al (2012) MiR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors. Dev Cell 22:1052–1064. https://doi.org/10.1016/j.devcel.2012.03.003
D’Alessandro R, Tinuper P, Ferrara R et al (1982) CT scan prediction of late post-traumatic epilepsy. J Neurol Neurosurg Psychiatry 45:1153–1155. https://doi.org/10.1136/jnnp.45.12.1153
Davies D, Yakoub KM, Scarpa U et al (2019) Serum miR-502: a potential biomarker in the diagnosis of concussion in a pilot study of patients with normal structural brain imaging. J Concussion 3:205970021988619. https://doi.org/10.1177/2059700219886190
Di Pietro V, Porto E, Ragusa M et al (2018) Salivary microRNAs: diagnostic markers of mild traumatic brain injury in contact-sport. Front Mol Neurosci 11:290. https://doi.org/10.3389/fnmol.2018.00290
Diallo A, Jacobi H, Cook A et al (2019) Prediction of survival with long-term disease progression in most common spinocerebellar ataxia. Mov Disord 34:1220–1227. https://doi.org/10.1002/mds.27739
Engel T, Murphy BM, Schindler CK, Henshall DC (2007) Elevated p53 and lower MDM2 expression in hippocampus from patients with intractable temporal lobe epilepsy. Epilepsy Res 77:151–156. https://doi.org/10.1016/j.eplepsyres.2007.09.001
Engel T, Tanaka K, Jimenez-Mateos EM et al (2010) Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus. Cell Death Dis 1:e79. https://doi.org/10.1038/cddis.2010.55
Enright N, Simonato M, Henshall DC (2018) Discovery and validation of blood microRNAs as molecular biomarkers of epilepsy: ways to close current knowledge gaps. Epilepsia Open 3:427–436. https://doi.org/10.1002/epi4.12275
Fisher RS, van Emde Boas W, Blume W et al (2005) Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 46:470–472. https://doi.org/10.1111/j.0013-9580.2005.66104.x
Gross C, Tiwari D (2018) Regulation of Ion channels by microRNAs and the implication for epilepsy. Curr Neurol Neurosci Rep 18:1–11. https://doi.org/10.1007/S11910-018-0870-2/TABLES/1
Guo D, Li Q, Lv Q et al (2014) MiR-27a targets sFRP1 in hFOB cells to regulate proliferation, apoptosis and differentiation. PLoS One 9:e91354. https://doi.org/10.1371/journal.pone.0091354
Guo Z, Gao W-S, Wang Y-F et al (2021) MiR-502 suppresses TNF-α-induced nucleus pulposus cell apoptosis by targeting TARF2. https://doi.org/10.1155/2021/5558369
Han S, Zou H, Lee JW et al (2019) MiR-1307-3p stimulates breast cancer development and progression by targeting SMYD4. J Cancer 10:441–448. https://doi.org/10.7150/jca.30041
Hanna J, Hossain GS, Kocerha J (2019) The potential for microRNA therapeutics and clinical research. Front Genet 10:478. https://doi.org/10.3389/fgene.2019.00478
He T, Chen P, Jin L et al (2018) MiR-660-5p is associated with cell migration, invasion, proliferation and apoptosis in renal cell carcinoma. Mol Med Rep 17:2051–2060. https://doi.org/10.3892/mmr.2017.8052
Hu K (2021) Become Competent in Generating RNA-Seq Heat Maps in One Day for Novices Without Prior R Experience. In: Methods in Molecular Biology. Humana Press Inc., pp 269–303. https://doi.org/10.1007/978-1-0716-1084-8_17
Jimenez-Mateos EM, Henshall DC (2013) Epilepsy and microRNA. Neuroscience 238:218–229. https://doi.org/10.1016/j.neuroscience.2013.02.027
Johnson JJ, Loeffert AC, Stokes J et al (2018) Association of salivary microRNA changes with prolonged concussion symptoms. JAMA Pediatr 172:65–73. https://doi.org/10.1001/jamapediatrics.2017.3884
Juźwik CA, Drake SS, Zhang Y et al (2019) microRNA dysregulation in neurodegenerative diseases: a systematic review. Prog Neurobiol 182. https://doi.org/10.1016/j.pneurobio.2019.101664
Kaalund SS, Venø MT, Bak M et al (2014) Aberrant expression of miR-218 and miR-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis-convergence on axonal guidance. Epilepsia 55:2017–2027. https://doi.org/10.1111/epi.12839
Kobylarek D, Iwanowski P, Lewandowska Z et al (2019) Advances in the potential biomarkers of epilepsy. Front Neurol 10:685. https://doi.org/10.3389/fneur.2019.00685
Krichevsky AM, Gabriely G (2008) miR-21: a small multi-faceted RNA. J Cell Mol Med 13:39–53. https://doi.org/10.1111/j.1582-4934.2008.00556.x
Levira F, Thurman DJ, Sander JW et al (2017) Premature mortality of epilepsy in low- and middle-income countries: a systematic review from the Mortality Task Force of the International League Against Epilepsy. Epilepsia 58:6–16. https://doi.org/10.1111/epi.13603
Li X, Giri V, Cui Y et al (2019) LncRNA FTX inhibits hippocampal neuron apoptosis by regulating miR-21-5p/SOX7 axis in a rat model of temporal lobe epilepsy. Biochem Biophys Res Commun 512:79–86. https://doi.org/10.1016/j.bbrc.2019.03.019
Liliang PC, Liang CL, Weng HC et al (2010) τ proteins in serum predict outcome after severe traumatic brain injury. J Surg Res 160:302–307. https://doi.org/10.1016/j.jss.2008.12.022
Liu R, Wang W, Wang S et al (2018) microRNA-21 regulates astrocytic reaction post-acute phase of spinal cord injury through modulating TGF-β signaling. Aging (albany NY) 10(6):1474–1488. https://doi.org/10.18632/aging.101484
Natarajan L, Minya Pu, Messer K (2012) Statistical tests for the intersection of independent lists of genes: Sensitivity, FDR, and type I error control. Ann Appl Stat 6(2):521–541. https://doi.org/10.1214/11-AOAS510
Lu J, Zhou N, Yang P, Deng L et al (2019) MicroRNA-27a-3p downregulation inhibits inflammatory response and hippocampal neuronal cell apoptosis by upregulating mitogen-activated protein Kinase 4 (MAP2K4) expression in epilepsy: in vivo and in vitro studies. Med Sci Monit 25:8499–8508. https://doi.org/10.12659/MSM.916458
Ma Y (2017) The challenge of microRNA as a biomarker of epilepsy. Curr Neuropharmacol 16. https://doi.org/10.2174/1570159x15666170703102410
Ma Z, Shuai Y, Gao X et al (2020) Circular RNAs in the tumour microenvironment. Mol Cancer 19:1–22. https://doi.org/10.1186/s12943-019-1113-0
McKiernan RC, Jimenez-Mateos EM, Bray I et al (2012) Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis. PLoS One 7:e35921. https://doi.org/10.1371/journal.pone.0035921
Meng F, Wang F, Wang L et al (2016) MiR-30a-5p overexpression may overcome EGFR-inhibitor resistance through regulating PI3K/AKT signaling pathway in non-small cell lung cancer cell lines. Front Genet 7:197. https://doi.org/10.3389/fgene.2016.00197
Mencio CP, Hussein RK, Yu P, Geller HM (2021) The role of chondroitin sulfate proteoglycans in nervous system development. J Histochem Cytochem 69:61–80. https://doi.org/10.1369/0022155420959147/ASSET/IMAGES/LARGE/10.1369_0022155420959147-FIG2.JPEG
Mishra A, Verma M (2010) Cancer biomarkers: Are we ready for the prime time? Cancers (basel) 2:190–208. https://doi.org/10.3390/cancers2010190
O’Brien J, Hayder H, Zayed Y, Peng C (2018) Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne) 9:402. https://doi.org/10.3389/fendo.2018.00402
Okonkwo DO, Yue JK, Puccio AM et al (2013) GFAP-BDP as an acute diagnostic marker in traumatic brain injury: Results from the prospective transforming research and clinical knowledge in traumatic brain injury study. J Neurotrauma 30:1490–1497. https://doi.org/10.1089/neu.2013.2883
Peng B, Li C, He L et al (2020) miR-660-5p promotes breast cancer progression through down-regulating TET2 and activating PI3K/AKT/mTOR signaling. Braz J Med Biol Res 53:1–10. https://doi.org/10.1590/1414-431x20209740
Petrescu GED, Sabo AA, Torsin LI et al (2019) MicroRNA based theranostics for brain cancer: basic principles. J Exp Clin Cancer Res 38:231. https://doi.org/10.1186/s13046-019-1180-5
Pietro V Di, Yakoub KM, Scarpa U et al (2018) MicroRNA signature of traumatic brain injury: from the biomarker discovery to the point-of-care. Front Neurol 9:429. https://doi.org/10.3389/fneur.2018.00429
Pitkänen A, Paananen T, Kyyriäinen J et al (2021) Biomarkers for posttraumatic epilepsy. Epilepsy Behav 121. https://doi.org/10.1016/j.yebeh.2020.107080
Qi B, Wang Y, Chen ZJ et al (2017) Down-regulation of miR-30a-3p/5p promotes esophageal squamous cell carcinoma cell proliferation by activating the Wnt signaling pathway. World J Gastroenterol 23:7965–7977. https://doi.org/10.3748/wjg.v23.i45.7965
Qian FH, Deng X, Zhuang QX et al (2019) MiR-625-5p suppresses inflammatory responses by targeting AKT2 in human bronchial epithelial cells. Mol Med Rep 19:1951–1957. https://doi.org/10.3892/mmr.2019.9817
Qiu X, Dou Y (2017) miR-1307 promotes the proliferation of prostate cancer by targeting FOXO3A. Biomed Pharmacother 88:430–435. https://doi.org/10.1016/j.biopha.2016.11.120
Raoof R, Bauer S, El Naggar H et al (2018) Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy. EBioMedicine 38:127–141. https://doi.org/10.1016/j.ebiom.2018.10.068
Raoof R, Jimenez-Mateos EM, Bauer S et al (2017) Cerebrospinal fluid microRNAs are potential biomarkers of temporal lobe epilepsy and status epilepticus. Sci Rep 7:1–17. https://doi.org/10.1038/s41598-017-02969-6
Redell JB, Zhao J, Dash PK (2011) Altered expression of miRNA-21 and its targets in the hippocampus after traumatic brain injury. J Neurosci Res 89:212–221. https://doi.org/10.1002/jnr.22539
Reschke CR, Henshall DC (2015) Microrna and epilepsy. Advances in Experimental Medicine and Biology. Springer New York LLC, pp 41–70. https://doi.org/10.1007/978-3-319-22671-2_4
Rupaimoole R, Slack FJ (2017) MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov 16:203–221. https://doi.org/10.1038/nrd.2016.246
Sanz-Rubio D, Martin-Burriel I, Gil A et al (2018) Stability of circulating exosomal miRNAs in healthy subjects article. Sci Rep 8:10306. https://doi.org/10.1038/s41598-018-28748-5
Sekino Y, Sakamoto N, Sentani K et al (2019) miR-130b promotes sunitinib resistance through regulation of PTEN in renal cell carcinoma. Oncology 97:164–172. https://doi.org/10.1159/000500605
Sekuklu SD, Donoghue MTA, Spillane C (2009) miR-21 as a key regulator of oncogenic processes. In: Biochemical Society Transactions. Portland Press, pp 918–925. https://doi.org/10.1042/BST0370918
Sha HH, Wang DD, Chen D et al (2017) MiR-138: A promising therapeutic target for cancer. Tumor Biol 39:101042831769757. https://doi.org/10.1177/1010428317697575
Shen L, Xiao Y, Wu Q et al (2019) TLR4/NF-ΚB axis signaling pathway-dependent up-regulation of miR-625-5p contributes to human intervertebral disc degeneration by targeting COL1A1. Am J Transl Res 11:1374–1388
Singh G, Rees JH, Sander JW (2007) Seizures and epilepsy in oncological practice: causes, course, mechanisms and treatment. J Neurol Neurosurg Psychiatry 78(4):342–349. https://doi.org/10.1136/jnnp.2006.106211
Sinha PB, Tesfaye D, Rings F et al (2017) MicroRNA-130b is involved in bovine granulosa and cumulus cell’s function, oocyte maturation and blastocyst formation. J Ovarian Res 10(1):37. https://doi.org/10.1186/s13048-017-0336-1
Su Z, Yang Z, Xu Y et al (2015) MicroRNAs in apoptosis, autophagy and necroptosis. Oncotarget 6:8474–8490. https://doi.org/10.18632/oncotarget.3523
Sun D, van Klink NEC, Bongaarts A et al (2022) High frequency oscillations associate with neuroinflammation in low-grade epilepsy associated tumors. Clin Neurophysiol 133:165–174. https://doi.org/10.1016/J.CLINPH.2021.08.025
Sun LH, Yan ML, Hu XL et al (2015) MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion. Mol Neurodegener 10:1–15. https://doi.org/10.1186/S13024-015-0032-9/FIGURES/7
Sun L, Shan W, Yang H et al (2021) The role of neuroinflammation in post-traumatic epilepsy. Front Neurol 12:876. https://doi.org/10.3389/fneur.2021.646152
Saruwatari J, Ogusu N, Shimomasuda M, Nakashima H et al (2014) Effects of CYP2C19 and P450 oxidoreductase polymorphisms on the population pharmacokinetics of clobazam and N-desmethylclobazam in japanese patients with epilepsy. Ther Drug Monit 36(3):302–309. https://doi.org/10.1097/FTD.0000000000000015
Tan M, Shen L, Hou Y (2020) Epigenetic modification of BDNF mediates neuropathic pain via miR-30a-3p/EP300 axis in CCI rats. Biosci Rep 40:20194442. https://doi.org/10.1042/BSR20194442
Tang C, Gu YY, Wang H et al (2018) Targeting of microRNA-21-5p protects against seizure damage in a kainic acid-induced status epilepticus model via PTEN-mTOR. Epilepsy Res 144:34–42
Tao H, Zhao J, Liu T et al (2017) Intranasal delivery of miR-146a mimics delayed seizure onset in the lithium-pilocarpine mouse model. Mediators Inflamm 2017. https://doi.org/10.1155/2017/6512620
Tewari D, Sah AN, Bawari S et al (2021) Role of nitric oxide in neurodegeneration: function, regulation, and inhibition. Curr Neuropharmacol 19(2):114–126. https://doi.org/10.2174/1570159X18666200429001549
Thurman DJ, Beghi E, Begley CE et al (2011) Standards for epidemiologic studies and surveillance of epilepsy. Epilepsia 52(Suppl 7):2–26. https://doi.org/10.1111/j.1528-1167.2011.03121.x
Tian F, Yuan C, Yue H (2018) MiR-138/SIRT1 axis is implicated in impaired learning and memory abilities of cerebral ischemia/reperfusion injured rats. Exp Cell Res 367:232–240. https://doi.org/10.1016/j.yexcr.2018.03.042
Tripathi A, Volsko C, Garcia JP et al (2019) Oligodendrocyte intrinsic miR-27a controls myelination and remyelination. Cell Rep 29:904-919.e9. https://doi.org/10.1016/j.celrep.2019.09.020
Venø MT, Reschke CR, Morris G et al (2020) A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy. Proc Natl Acad Sci U S A 117:15977–15988. https://doi.org/10.1073/pnas.1919313117
Wang J, Tan L, Tan L et al (2015a) Circulating microRNAs are promising novel biomarkers for drug-resistant epilepsy. Sci Rep 5:1–10. https://doi.org/10.1038/srep10201
Wang J, Yu JT, Tan L et al (2015b) Genome-wide circulating microRNA expression profiling indicates biomarkers for epilepsy. Sci Rep 5:1–9. https://doi.org/10.1038/srep09522
Wang W, Ma Y-M, Jiang Z-L et al (2021) Apoptosis-antagonizing transcription factor is involved in rat post-traumatic epilepsy pathogenesis. Exp Ther Med 21:1–1. https://doi.org/10.3892/etm.2021.9721
Wang W, Zhao L-J, Tan Y-X et al (2012) MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma. Carcinogenesis 33:1113–1120. https://doi.org/10.1093/carcin/bgs113
Willmore LJ (1990) Post-traumatic epilepsy: cellular mechanisms and implications for treatment. Epilepsia 31. https://doi.org/10.1111/j.1528-1157.1990.tb05861.x
Wu Y, Zhang Y, Wang F et al (2020) MiR-660-5p promotes the progression of hepatocellular carcinoma by interaction with YWHAH via PI3K/Akt signaling pathway. Biochem Biophys Res Commun 531:480–489. https://doi.org/10.1016/j.bbrc.2020.07.034
Xiao L, Zhou H, Li XP et al (2016) MicroRNA-138 acts as a tumor suppressor in non small cell lung cancer via targeting YAP1. Oncotarget 7:40038–40046. https://doi.org/10.18632/oncotarget.9480
Xie Y, Wang M, Shao Y et al (2019) Long non-coding RNA KCNQ1OT1 contributes to antiepileptic drug resistance through the miR-138-5p/ABCB1 axis in vitro. Front Neurosci 13:1358. https://doi.org/10.3389/fnins.2019.01358
Yan J, Ying S, Cai X (2018) MicroRNA-mediated regulation of HMGB1 in human hepatocellular carcinoma. Biomed Res Int 2018:2754941. https://doi.org/10.1155/2018/2754941
Yang L, Wang Y, Shi S et al (2018) The TNF-α-induced expression of miR-130b protects cervical cancer cells from the cytotoxicity of TNF-α. FEBS Open Bio 8:614–627. https://doi.org/10.1002/2211-5463.12395
Ye X, Yu H, Jin Y et al (2015) miR-138 inhibits proliferation by targeting 3-phosphoinositide-dependent protein kinase-1 in non-small cell lung cancer cells. Clin Respir J 9:27–33. https://doi.org/10.1111/crj.12100
Yin H, He H, Shen X et al (2020) miR-9-5p inhibits skeletal muscle satellite cell proliferation and differentiation by targeting IGF2BP3 through the IGF2-PI3K/Akt signaling pathway. Int J Mol Sci 21:1655. https://doi.org/10.3390/ijms21051655
Yu T, Cao R, Li S et al (2015) MiR-130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells. BMC Cancer 15:1–9. https://doi.org/10.1186/s12885-015-1031-5
Yuan J, Huang H, Zhou X et al (2016) MicroRNA-132 interact with p250GAP/Cdc42 pathway in the hippocampal neuronal culture model of acquired epilepsy and associated with epileptogenesis process. Neural Plast 2016. https://doi.org/10.1155/2016/5108489
Yuva-Aydemir Y, Simkin A, Gascon E, Gao F-B (2011) MicroRNA-9. RNA Biol 8:557–564. https://doi.org/10.4161/rna.8.4.16019
Zhang G, Sun Y, Wang Y et al (2016) MiR-502-5p inhibits IL-1β-induced chondrocyte injury by targeting TRAF2. Cell Immunol 302:50–57. https://doi.org/10.1016/j.cellimm.2016.01.007
Zhang H, Zhang Z, Wang S et al (2018) The mechanisms involved in miR-9 regulated apoptosis in cervical cancer by targeting FOXO3. Biomed Pharmacother 102:626–632. https://doi.org/10.1016/j.biopha.2018.03.019
Zhang J, Cao Z, Yang G et al (2019a) MicroRNA-27a (miR-27a) in solid tumors: a review based on mechanisms and clinical observations. Front Oncol 9:893. https://doi.org/10.3389/fonc.2019.00893
Zhang LY, Chen Y, Jia J et al (2019b) MiR-27a promotes EMT in ovarian cancer through active Wnt/o œ •-catenin signalling by targeting FOXO1. Cancer Biomark 24:31–42. https://doi.org/10.3233/CBM-181229
Zhang L, Zhao W, Bao D et al (2021) miR-9–5p promotes wear-particle-induced osteoclastogenesis through activation of the SIRT1/NF-κB pathway. 3 Biotech 11:1–12. https://doi.org/10.1007/s13205-021-02814-8
Zhao G, Zhang J, Shi Y et al (2013) MiR-130b is a prognostic marker and inhibits cell proliferation and invasion in pancreatic cancer through targeting STAT3. PLoS One 8:e73803. https://doi.org/10.1371/journal.pone.0073803
Zhu M, Chen J, Guo H et al (2018) High mobility group protein B1 (HMGB1) and interleukin-1β as prognostic biomarkers of epilepsy in children. J Child Neurol 33:909–917. https://doi.org/10.1177/0883073818801654
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Kumar, P. miRNA dysregulation in traumatic brain injury and epilepsy: a systematic review to identify putative biomarkers for post-traumatic epilepsy. Metab Brain Dis 38, 749–765 (2023). https://doi.org/10.1007/s11011-023-01172-z
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DOI: https://doi.org/10.1007/s11011-023-01172-z