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Suppressive role of lovastatin in intracerebral hemorrhage through repression of autophagy

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Abstract

Statins possess critical function in the brain. Here, we intended to investigate the role of lovastatin in brain damage after intracerebral hemorrhage (ICH). A collagenase-induced ICH rat model was established followed by lovastatin treatment. Then, the effect of lovastatin on ICH-induced brain damage was explored with cognitive function, learning and memory abilities, and neurological damage of rats analyzed. Besides, brain water content, number of degenerate neurons, Nissl's body, and apoptosis of neurons were detected. Oxidative stress levels, inflammation, and autophagy levels in ICH were measured after treatment of lovastatin. Lovastatin improved the cognitive impairment of rats, enhanced their spatial learning and memory abilities, reduced nervous system damage, lesion area, and brain water content after ICH. Lovastatin was capable of reducing the number of degenerated neurons, the apoptosis level, autophagy level, and increasing the number of Nissl's body. Lovastatin inhibited the oxidative stress response and inflammatory factors in the brain tissue after ICH, and increased the expression of anti-inflammatory factor IL-10. Lovastatin inhibited AMPK/mTOR signaling pathway after ICH. Our study highlighted the suppressive role of lovastatin in ICH-induced brain damage.

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Data availability

The datasets used or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

Thanks for the grant from the Shaoyang science and technology planning projec (Grant No. 2020GZ93).

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Authors and Affiliations

  1. Department of Neurosurgery, the First Affiliated Hospital of Shaoyang University, No. 39, Tongheng Street, Shuangqing District, Shaoyang, Hunan, 422001, People’s Republic of China

    Xiong Deng, Ruqi Qing, Pinhua Yue & Song Tian

  2. Department of Nursing, the First Affiliated Hospital of Shaoyang University, Shaoyang, Hunan, 422001, People’s Republic of China

    Jinmei Yang

  3. Health Management Center, the First Affiliated Hospital of Shaoyang University, Shaoyang, Hunan, 422001, People’s Republic of China

    Heying Yuan

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  1. Xiong Deng
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  2. Jinmei Yang
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  6. Song Tian
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Contributions

DX conceived the ideas. TS designed the experiments. DX performed the experiments. TS analyzed the data. YJM and QRQ provided critical materials. YHY and YPH wrote the manuscript. DX supervised the study. All the authors have read and approved the final version for publication.

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Correspondence to Song Tian.

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Animal experiments were carried out in accordance with the standards established by the Animal Experiment Committee of The First Affiliated Hospital of Shaoyang University, and were approved by the Ethics Committee of The First Affiliated Hospital of Shaoyang University. All animal experiments were carried out in accordance with the "Guidelines for the Care and Use of Laboratory Animals" issued by the National Institutes of Health (NIH).

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Deng, X., Yang, J., Qing, R. et al. Suppressive role of lovastatin in intracerebral hemorrhage through repression of autophagy. Metab Brain Dis 38, 361–372 (2023). https://doi.org/10.1007/s11011-022-01101-6

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