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Translocator protein 18 kDa: a potential therapeutic biomarker for post traumatic stress disorder

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Abstract

Post traumatic stress disorder (PTSD) is widely regarded as a stress-related and trauma disorder. The symptoms of PTSD are characterized as a spectrum of vulnerabilities after the exposure to an extremely traumatic stressor. Considering as one of complex mental disorders, little progress has been made toward its diagnostic biomarkers, despite the involvement of PTSD has been studied. Many studies into the underlying neurobiology of PTSD implicated the dysfunction of neurosteroids biosynthesis and neuorinflammatory processes. Translocator protein 18 kDa (TSPO) has been considered as one of the promising therapeutic biomarkers for neurological stress disorders (like PTSD, depression, anxiety, et al) without the benzodiazepine-like side effects. This protein participates in the formation of neurosteroids and modulation of neuroinflammation. The review outlines current knowledge involving the role of TSPO in the neuropathology of PTSD and the anti-PTSD-like effects of TSPO ligands.

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Acknowledgments

This study was supported by a grant from Natural Science Foundation of Guangdong Province, China (No. 2017A030313448), National Natural Science Foundation of China (No. 81703731) and Educational Commission of Guangdong Province, China (No. 2016KQNCX086).

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Authors and Affiliations

  1. Pharmaceutical Department of The First Affiliated Hospital of Guangdong Pharmaceutical University, Clinical Pharmacy Department of Guangdong Pharmaceutical University, Guangzhou, 510080, People’s Republic of China

    Zhi-Kun Qiu, Yong Chen, Rong-Jia Wu, Shi-Feng Guan, Yun-yun Pan, Qian-Bo Wang & Ji-Sheng Chen

  2. Pharmacy Department of Medical Supplies Center of General Hospital of Chinese People’s Armed Police Forces, Beijing, 100039, People’s Republic of China

    Xu Liu

  3. Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, People’s Republic of China

    Dan Tang & Tao Zhu

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Qiu, ZK., Liu, X., Chen, Y. et al. Translocator protein 18 kDa: a potential therapeutic biomarker for post traumatic stress disorder. Metab Brain Dis 35, 695–707 (2020). https://doi.org/10.1007/s11011-020-00548-9

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