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Exosomes from human umbilical cord Mesenchymal stem cells attenuates stress-induced hippocampal dysfunctions

Metabolic Brain Disease volume 35, pages 1329–1340 (2020)Cite this article

Abstract

Human Mesenchymal Stem Cells (MSCs) especially human umbilical cord MSCs is the novel regenerative cell resource for regenerative therapy. However, the biological underpinning of MSCs in neuroprotections requires deep understanding. Exosomes is an important biological factor due to its multiple types of contents with various biological function. In current study, we collected the exosome from umbilical cord mesenchymal stem cells (hUC-MSCs) and tested the neuroprotective effects to brain stress. Proteomic analysis indicates significant enriched protein components display the functions in metabolic regulation. We then injected the exosome (MSC-Ex) to adult mice by i.v injection. On physiological level, treatment of MSC-Ex increased the adiponectin level in peripheral central nervous system (CNS). Moreover, MSC-Ex significantly accelerated the differentiation of adult neural stem cells but did not benefit the related cognitive behavior. We then created acute brain disorder model with STZ intra-hippocampal injection. Compared with STZ group, treatment of MSC-Ex improved cognitive function. Moreover, MSC-Ex promotes hippocampal neurogenesis that was suppressed by STZ injection. In conclusion, hUC-MSCs derived exosome would exert the neural regenerative effects associating with its metabolism regulatory capacity.

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Acknowledgements

This research was supported by National Natural Science Foundation of China (81370312), and Shanxi National Natural Science Foundation (201801D121313). We thank the support from Department of Gynaecology and Obstetrics, Second Hospital Shanxi Medical University.

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Affiliations

  1. Department of Biochemistry and Molecular Biology, Shanxi Medical University, 56, Xinjian South Rd., Taiyuan, China

    Yuhu Niu, Meining Li & Bo Niu

  2. Department of Biotechnology, Capital Institute of Pediatric, Beijing, China

    Xiuwei Wang & Bo Niu

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  1. Yuhu Niu
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  2. Xiuwei Wang
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  3. Meining Li
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  4. Bo Niu
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Correspondence to Bo Niu.

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Niu, Y., Wang, X., Li, M. et al. Exosomes from human umbilical cord Mesenchymal stem cells attenuates stress-induced hippocampal dysfunctions. Metab Brain Dis 35, 1329–1340 (2020). https://doi.org/10.1007/s11011-019-00514-0

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Keywords

  • Human umbilical cord Mesenchymal stem cells
  • Exosome
  • Neurodegeneration