Effect of methamphetamine on the fasting blood glucose in methamphetamine abusers

Zhang, Yanhong; Shu, Guofang; Bai, Ying; Chao, Jie; Chen, Xufeng; Yao, Honghong

doi:10.1007/s11011-018-0265-8

Original Article
Published: 26 June 2018

Effect of methamphetamine on the fasting blood glucose in methamphetamine abusers

Yanhong Zhang¹,
Guofang Shu²,
Ying Bai¹,
Jie Chao³,
Xufeng Chen⁴ &
Honghong Yao ORCID: orcid.org/0000-0002-2128-0529^1,5

Metabolic Brain Disease volume 33, pages 1585–1597 (2018)Cite this article

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Abstract

Methamphetamine is a popular psychostimulant worldwide which causes neurotoxicity and neuroinflammation. Although previous studies have characterized potential associations between addictive drugs and fasting blood glucose, the influence of methamphetamine on the blood glucose is still largely unknown. The present study was designed to investigate the change of fasting blood glucose of methamphetamine abusers and to confirm the impairment of liver and kidney. Fasting blood glucose was significantly decreased in methamphetamine abusers and in a high-fat diet mouse model with methamphetamine treatment discontinuation. Serum level of ALT, creatine kinase and creatinine were increased in methamphetamine abusers. Serum level of ALT and AST were increased in a high-fat diet mouse model after methamphetamine injection, but there was no significant difference in the anatomy of the liver and kidney in high-fat diet treated mice with or without methamphetamine. The levels of ALT and creatinine were also increased in the methamphetamine abusers. This study demonstrated that the level of glucose was decreased in methamphetamine abusers and in high-fat diet-fed mice after methamphetamine treatment discontinuation. The effect of methamphetamine on the levels of blood glucose may provide the evidence that methamphetamine abusers should be keep energy balance due to the low blood glucose.

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Abbreviations

ALT:: Alanine aminotransferase
AST:: Aspartate aminotransferase
CNS:: Central nervous system
CPK:: Creatinine phosphokinase
ALP:: Alkaline phosphatase
EDTA:: Ethylenediaminetetraacetic acid
HFD:: High fat diet
TG:: Triglyceride
TC:: Total Cholesterol
LDL-C:: Low density lipoproteins cholesterol
HDL-C:: High density lipoproteins cholesterol
CK:: Creatine Kinase
Cr:: Creatinine
BUN:: Urea nitrogen

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Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (No. 81322048 and No. 81473190).

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Affiliations

Department of Pharmacology, Medical School of Southeast University, Nanjing, China
Yanhong Zhang, Ying Bai & Honghong Yao
Department of Clinical Laboratory, Zhongda Hospital, Southeast University School of Medicine, Nanjing, 210009, Jiangsu, China
Guofang Shu
Department of Physiology, Medical School of Southeast University, Nanjing, China
Jie Chao
Department of Emergency, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, China
Xufeng Chen
Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, Jiangsu, China
Honghong Yao

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Yanhong Zhang
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Guofang Shu
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Ying Bai
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Jie Chao
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Xufeng Chen
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Honghong Yao
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Contributions

Y.H. planned and designed the research, supervised and wrote the experiments; Y.H.Z carried out the experiments and wrote the manuscript; Y.B. participated in data acquisition and analysis; G.F.S and J.C participated in the design of study, drafted manuscript and coordinated the lab work; and X.F.C provided the comments on the manuscript, edited the writing, and involved in revising it critically for important intellectual content. All authors read and approved the final manuscript.

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Correspondence to Xufeng Chen or Honghong Yao.

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Zhang, Y., Shu, G., Bai, Y. et al. Effect of methamphetamine on the fasting blood glucose in methamphetamine abusers. Metab Brain Dis 33, 1585–1597 (2018). https://doi.org/10.1007/s11011-018-0265-8

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Received: 21 March 2018
Accepted: 04 June 2018
Published: 26 June 2018
Issue Date: October 2018
DOI: https://doi.org/10.1007/s11011-018-0265-8

Keywords

Methamphetamine
Serum biochemical parameters
Liver
Kidney