New views and possibilities of antidiabetic drugs in treating and/or preventing mild cognitive impairment and Alzheimer’s Disease
Mounting evidence suggests that diabetes mellitus (DM) is associated with mild cognitive impairment (MCI), vascular dementia and Alzheimer’s disease (AD). Biological, clinical and epidemiological data support a close link between DM and AD. Increasingly, studies have found that several antidiabetic agents can promote neurogenesis, and clinically ameliorate cognitive and memory impairments in different clinical settings. Data has shown that these antidiabetic drugs positively affect mitochondrial and synaptic function, neuroinflammation, and brain metabolism. Evidence to date strongly suggests that these antidiabetic drugs could be developed as disease-modifying therapies for MCI and AD in patients with and without diabetes.
KeywordsAntidiabetic drugs Diabetes mellitus Mild cognitive impairment Alzheimer’s disease Insulin resistance
This work was supported by grants from the National Natural Science Foundation of China (81573413 and 81773714 to to Hao Hong, 81603113 to Su Su Tang), the Natural Science Foundation of Jiangsu Province (BK20150705 to Su Su Tang) and the Fundamental Research Funds for the Central Universities (2632017PT01).
Compliance with ethical standards
Conflict of interest
We declare that all authors have no conflict of interest.
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