Metabolic Brain Disease

, Volume 33, Issue 3, pp 705–711 | Cite as

Zeaxanthin improved diabetes-induced anxiety and depression through inhibiting inflammation in hippocampus

  • Xiaoyan Zhou
  • Tian Gan
  • Gaoxia Fang
  • Shangshang Wang
  • Yizhen Mao
  • Changjiang Ying
Original Article

Abstract

It is generally accepted that inflammation plays a key role in anxiety and depression induced by diabetes. However, the underlying mechanism and effective treatment method of these diabetes-associated behavior disorders remain to be determined. In the present study, we attempted to illuminate the implication of zeaxanthin in anxiety, depression and neuroinflammation caused by hyperglycemia, and further elaborate the relevant mechanism under these neuropsychiatric disorders. In the current work, diabetic rats were induced by high glucose and fat diet followed by a single intraperitoneal injection of streptozocin, and zeaxanthin was orally administration every day (From 6th to 19th week). Diabetes-associated anxiety and depression were assessed using open field test (OFT) and Forced swimming test (FST) respectively. Moreover, the levels of interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in hippocampus were tested using ELISA and WB. Data showed that long-term zeaxanthin treatment improve diabetic symptoms and alleviate anxiety and depression in diabetic rats. Furthermore, excessive production of IL-6, IL-1β and TNF-α could be reduced with zeaxanthin treatment. In conclusion, we suggested that zeaxanthin can ameliorate diabetes-associated anxiety and depression, inhibit inflammation in diabetic rats. Our results could provide a potential therapeutic approach for the treatment of abnormal behavior induced by hyperglycemia.

Keywords

Zeaxanthin Diabetes Anxiety Depression Inflammation 

Notes

Acknowledgements

This work was supported by a grant from the National Natural Science Foundation of China (81701298) and the Department of Science & Technology, Xuzhou, Jiangsu, China (No. KC14SH094).

Compliance with ethical standards

Conflict of interest

All authors state that there is no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  • Xiaoyan Zhou
    • 1
  • Tian Gan
    • 2
  • Gaoxia Fang
    • 2
  • Shangshang Wang
    • 2
  • Yizhen Mao
    • 2
  • Changjiang Ying
    • 3
  1. 1.Laboratory of MorphologyXuzhou Medical UniversityXuzhouPeople’s Republic of China
  2. 2.The Graduate SchoolXuzhou Medical UniversityXuzhouPeople’s Republic of China
  3. 3.Department of EndocrinologyAffiliated Hospital of Xuzhou Medical UniversityXuzhouPeople’s Republic of China

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