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Metabolic Brain Disease

, Volume 32, Issue 6, pp 1767–1783 | Cite as

MicroRNA expression signature of methamphetamine use and addiction in the rat nucleus accumbens

  • Maw Shin SimEmail author
  • Tomoko Soga
  • Vijayapandi Pandy
  • Yuan Seng Wu
  • Ishwar S. Parhar
  • Zahurin MohamedEmail author
Original Article

Abstract

Methamphetamine (METH) is a highly addictive psycho-stimulant that induces behavioral changes due to high level of METH-induced dopamine in the brain. Nucleus accumbens (NAc) plays an important role in these changes, especially in drug addiction. However, little is known about the underlying molecular mechanisms of METH-induced addiction. The objective of this study was to establish a behavioral model of METH use and addiction using escalating doses of METH over 15 days and to determine the global miRNA expression profiling in NAc of METH-addicted rats. In the behavioral study, the experimental rats were divided into 3 groups of 9 each: a control group, a single dose METH (5 mg/kg) treatment group and a continuous 15 alternate days METH (0.25, 0.5, 1, 2, 3, 4, 5 mg/kg) treatment group. Following that, six rats in each group were randomly selected for global miRNA profiling. Addiction behavior in rats was established using Conditioned Place Preference task. The analysis of the miRNA profiling in the NAc was performed using Affymetric microarray GeneChip® System. The findings indicated that a continuous 15 alternate days METH treatment rats showed a preference for the drug-paired compartment of the CPP. However, a one-time acute treatment with 5 mg/kg METH did not show any significant difference in preference when compared with controls. Differential profiling of miRNAs indicated that 166 miRNAs were up-regulated and 4 down-regulated in the chronic METH-treatment group when compared to controls. In comparing the chronic treatment group with the acute treatment group, 52 miRNAs were shown to be up-regulated and 7 were down-regulated. MiRNAs including miR-496-3p, miR-194-5p, miR-200b-3p and miR-181a-5p, were found to be significantly associated with METH addiction. Canonical pathway analysis revealed that a high number of METH addiction-related miRNAs play important roles in the MAPK, CREB, G-Protein Couple Receptor and GnRH Signaling pathways. Our results suggest that dynamic changes occur in the expression of miRNAs following METH exposure and addiction.

Keywords

Methamphetamine addiction microRNA profiling nucleus accumbens 

Abbreviations

miRNA

microRNA

SEM

standard error of the mean

qPCR

real-time polymerase chain reaction

RIN

RNA Integrity Number

MAPK

mitogen-activated protein kinases

CREB

cAMP response element-binding protein

GnRH

Gonadotropin-releasing hormone

BDNF

brain-derived neurotrophic factor

PKA

protein kinase A

PKC

protein kinase C

Notes

Compliance with ethical standards

Ethical approval

All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted.

Financial disclosure

This work was supported by Research University Grant RG443/12HTM from the University of Malaya and High Impact Research (HIR) Ministry of Higher Education (MOHE) Grant H20001-E000025. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Statement of interest

All the authors declare that they have no conflicts of interest to report that could inappropriately influence, or be perceived to influence, this work. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Supplementary material

11011_2017_61_MOESM1_ESM.doc (149 kb)
Supplementary Table 1 (DOC 149 kb)
11011_2017_61_MOESM2_ESM.doc (144 kb)
Supplementary Table 2 (DOC 144 kb)

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Maw Shin Sim
    • 1
    Email author
  • Tomoko Soga
    • 2
  • Vijayapandi Pandy
    • 1
  • Yuan Seng Wu
    • 1
  • Ishwar S. Parhar
    • 2
  • Zahurin Mohamed
    • 1
    Email author
  1. 1.Department of Pharmacology, Faculty of MedicineUniversity of MalayaKuala LumpurMalaysia
  2. 2.Brain Research Institute, School of Medicine and Health SciencesMonash UniversityBandar SunwayMalaysia

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