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Thalamic resting-state functional connectivity: disruption in patients with type 2 diabetes

Metabolic Brain Disease volume 30, pages 1227–1236 (2015)Cite this article

Abstract

To explore the disrupted thalamic functional connectivity and its relationships with cognitive dysfunction in type 2 diabetes mellitus (T2DM) by using resting-state functional magnetic resonance imaging (fMRI). A total of 38 T2DM patients and 39 well-matched healthy controls participated in the resting-state fMRI and T1-weighted imaging scans. The thalamic functional connectivity was characterized by using a seed-based whole-brain correlation method and compared T2DM patients with healthy controls. Pearson correlation analysis was performed between thalamic functional connectivity and clinical data. When compared with healthy controls, T2DM showed significantly decreased functional connectivity of the thalamus mainly in the right middle temporal gyrus (MTG), right precentral gyrus and bilateral occipital cortex; Increased functional connectivity of the thalamus was detected in the left cerebellum, bilateral middle frontal gyrus and middle cingulate gyrus (p < 0.05, corrected for AlphaSim). In T2DM patients, the decreased thalamic functional connectivity of the right MTG was positively associated with the Verbal Fluency Test score (r = 0.438, p = 0.006). Meanwhile, the decreased thalamic functional connectivity of the right cuneus was positively correlated with the Complex Figure Test-delayed score and negatively correlated with the Trail Making Test-B score, respectively (r = 0.492, p = 0.002; r = −0.504, p = 0.001). Moreover, there was no structural damage in the thalamus of T2DM patients. T2DM patients develop disrupted thalamocortical functional connectivity, which is associated with cognitive impairment in selected brain regions. Resting-state thalamocortical connectivity disturbance may play a central role in the underlying neuropathological process of T2DM-related cognitive dysfunction.

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Acknowledgments

The authors thank the contribution of Yu-Feng Zang, Center for Cognition and Brain Disorders and the affiliated hospital, Hangzhou Normal University, Hangzhou, China. This work was supported by the Major State Basic Research Development Program of China (973 Program) (NOs.2013CB733800, 2013CB733803), National Natural Science Foundation of China (NOs.81230034, 81271739), Jiangsu Provincial Special Program of Medical Science (NO.BL2013029), Key Project of Jiangsu Province Natural Science Foundation of China (NO. BK20130057), Fundamental Research Funds for the Central Universities and Jiangsu Graduate Student Innovation Grant (NO.KYZZ_0076, KYZZ_0073). Y.C.C acknowledges the financial support from the China Scholarship Council for his joint PhD scholarship (NO. 201406090139). Y.C.C. collected the data, performed the analysis and wrote the manuscript. W.X designed the experiment and revised the manuscript. C.Q., J.D., S.J. and G.J.T contributed to the discussion and manuscript revision.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all patients for being included in the study.

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Affiliations

  1. Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87# Dingjiaqiao Road, Nanjing, 210009, China

    Yu-Chen Chen, Cheng Qian, Jie Ding, Shenghong Ju & Gao-Jun Teng

  2. Medical School, Southeast University, Nanjing, China

    Wenqing Xia

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  1. Yu-Chen Chen
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  2. Wenqing Xia
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Correspondence to Gao-Jun Teng.

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Yu-Chen Chen and Wenqing Xia contributed equally to this paper.

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Chen, YC., Xia, W., Qian, C. et al. Thalamic resting-state functional connectivity: disruption in patients with type 2 diabetes. Metab Brain Dis 30, 1227–1236 (2015). https://doi.org/10.1007/s11011-015-9700-2

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Keywords

  • T2DM
  • Thalamus
  • Functional connectivity
  • FMRI