Metabolic Brain Disease

, Volume 30, Issue 3, pp 785–792 | Cite as

Neuroprotective activity of hydroponic Teucrium polium following bilateral ovariectomy

  • K. V. Simonyan
  • V. A. Chavushyan
Research Article


Ovariectomy is known as “surgical menopause” with decreased levels of estrogen in female rodents. Its reported risks and adverse effects include cognitive impairment. The action of hydroponic Teucrium polium on nucleus basalis of Meynert (bnM) neurons following 6 weeks of ovariectomy was carried out. The analysis of spike activity was observed by on-line selection and the use of a software package. Early and late tetanic, − posttetanic potentiation and depression of neurons to high frequency stimulation of hippocampus were studied. The complex averaged peri-event time and frequency histograms were constructed. The histochemical study of the activity of Са2+-dependent acid phosphatase was observed. In conditions of hydroponic Teucrium polium administration, positive changes in neurons and gain of metabolism leading to cellular survival were revealed. The administration of Teucrium polium elicited neurodegenerative changes in bnM.


Ovariectomy Nucleus basalis of Meynert Teucrium polium Са2+-dependent acid phosphatase 


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Laboratory of Neuroendocrine RelationshipsOrbeli Institute of PhysiologyYerevanArmenia

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