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TAM receptor deficiency affects adult hippocampal neurogenesis

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Abstract

The Tyro3, Axl and Mertk (TAM) subfamily of receptor protein tyrosine kinases functions in cell growth, differentiation, survival, and most recently found, in the regulation of immune responses and phagocytosis. All three receptors and their ligands, Gas6 (growth arrest-specific gene 6) and protein S, are expressed in the central nervous system (CNS). TAM receptors play pivotal roles in adult hippocampal neurogenesis. Loss of these receptors causes a comprised neurogenesis in the dentate gyrus of adult hippocampus. TAM receptors have a negative regulatory effect on microglia and peripheral antigen-presenting cells, and play a critical role in preventing overproduction of pro-inflammatory cytokines detrimental to the proliferation, differentiation, and survival of adult neuronal stem cells (NSCs). Besides, these receptors also play an intrinsic trophic function in supporting NSC survival, proliferation, and differentiation into immature neurons. All these events collectively ensure a sustained neurogenesis in adult hippocampus.

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Abbreviations

NSC:

Neural stem cell

DG:

Dentate gyrus

TAM:

Tyro3, Axl, and Mertk

TKO:

Triple knockout

BrdU:

5-bromo-2′-deoxyuridine

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, 301 E. Muhammad Ali Blvd, Louisville, KY, 40202, USA

    Rui Ji, Qiutang Li & Qingxian Lu

  2. Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, 301 E. Muhammad Ali Blvd, Louisville, KY, 40202, USA

    Rui Ji, Lingbin Meng & Qingxian Lu

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  1. Rui Ji
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  2. Lingbin Meng
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  3. Qiutang Li
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Correspondence to Qingxian Lu.

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Ji, R., Meng, L., Li, Q. et al. TAM receptor deficiency affects adult hippocampal neurogenesis. Metab Brain Dis 30, 633–644 (2015). https://doi.org/10.1007/s11011-014-9636-y

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