Skip to main content

Evaluation of the antipsychotic potential of aqueous fraction of Securinega virosa root bark extract in mice

Abstract

Securinega virosa (Roxb ex. Willd) Baill. is a plant which is commonly used in African traditional medicine in management of mental illness. Previous study showed that the crude methanolic root bark extract of the plant possesses antipsychotic activity. In this study, the antipsychotic potential of the residual aqueous fraction of the plant was evaluated using two experimental models, apomorphine induced stereotypic climbing behaviour and swim induced grooming, all in mice. The effect of the fraction on haloperidol-induced catalepsy was also evaluated. The fraction significantly reduced the mean climbing score at the highest dose tested (500 mg/kg). In the swim-induced grooming test, the fraction significantly and dose-dependently (125–500 mg/kg) decreased the mean number and mean duration of swim-induced grooming activity in mice. Similarly, the standard haloperidol (1 mg/kg) significantly (p < 0.001) decreased the mean grooming episodes and duration. However, the fraction did not significantly potentiate haloperidol-induced catalepsy. These results suggest that the residual aqueous fraction of methanol root bark extract of Securinega virosa contains biological active principle with antipsychotic potential.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2

References

  1. Chesher GB, Jackson DM (1981) Swim-induced grooming in mice is mediated by a dopaminergic substrate. J Neural Transm 50(1):47–55. doi:10.1007/bf01254913

    CAS  PubMed  Article  Google Scholar 

  2. Costall B, Fortune DH, Naylor RJ, Marsden CD, Pycock CJ (1975) Serotonergic involvement with neuroleptic catalepsy. Neuropharmacol 14:859–868. doi:10.1016/0028-3908(75)90114-8

    CAS  Article  Google Scholar 

  3. Costall B, Naylor RJ, Nohria V (1978) Climbing behavior-induced by apomorphine in mice: a potent model for the detection of neuroleptic activity. Eur J Pharmacol 50:39–50

    CAS  PubMed  Article  Google Scholar 

  4. Dalziel JM (1936) The useful plants of West Tropical Africa. Watmonghs, Idle, London, pp 354–355

    Google Scholar 

  5. Ehmann T, Yager J, Hanson L (2004) Early psychosis: a review of the treatment literature. Child Ment Health Pol Res Prog 7:1–52

    Google Scholar 

  6. Farde L, Nordstrom AL, Wiesel FA, Pauli S, Halldin C, Sedvall G (1992) PET-analysis of central D-2 and D2-dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine: relation to extrapyramidal side effects. Arch Gen Psychiatry 49:538–544

    CAS  PubMed  Article  Google Scholar 

  7. Hoffman DC, Donovan H (1995) Catalepsy as a rodent model for detecting antipsychotic drugs with extrapyramidal side effect liability. Psychopharmacology 120:128–133. doi:10.1007/BF02246184

    CAS  PubMed  Article  Google Scholar 

  8. Ingale SP, Kasture SB (2012) Psychopharmacological profile of Passiflora incarnata linn in mice. Int J Phytopharmacol 3(3):263–268

    Google Scholar 

  9. Kedves R, Saghy K, Gyertyan I (2008) Comparison of the effects of antipsychotic drugs in two antipsychotic screening assays: Swim-induced grooming and apomorphine-induced climbing test in mice. In: Ballintijn MR, Bogers ND, Grieco F, Loijen LWS, Noldus LPJJ, Smit G, Zimmerman PH (eds) Proceedings of Measuring behavior Spink AJ. Maastricht, The Netherlands, August, pp 26–29

    Google Scholar 

  10. Magaji MG, Anuka JA, Abdu-Aguye I, Yaro AH, Hussaini IM (2008) Behavioural effects of the methanolic root bark extract of Securinega virosa in rodents. Afr J tradit Complement Altern Med 5(2):147–153

    CAS  PubMed Central  PubMed  Google Scholar 

  11. Magaji MG, Yaro AH, Musa AM, Anuka JA, Abdu-Aguye I, Hussaini IM (2011) Sedative activity of residual aqueous fraction of Securinega virosa (Roxb. ex Willd) Baill. Root bark extract in mice. Niger J Pharm Sci 10(2):34–44

    Google Scholar 

  12. Moore NA, Axton MS (1988) Production of climbing behaviour in mice requires both D1 and D2 receptors activation. Psychopharmacology 94:261–269

    Article  Google Scholar 

  13. Nair V, Arjuman A, Dorababu P, Gopalakrishna U, Rao C, Mohan L (2007) Effect of NR-ANX-C (a polyherbal formulation) on haloperidol induced catalepsy in albino mice. Indian J Med Res 126:480–484

    CAS  PubMed  Google Scholar 

  14. National Research Council Guide for the Care and Use of Laboratory Animals (1996) Guide for the care and use of Laboratory Animals. A report of the Institute of Laboratory Animal Resource Committee on the care and use of laboratory animals. NIH publication no. 85–23. U.S. Department of Health and Human Services, Washington, DC

  15. Neuwinger JD (translated from the German by Porter A) (1996) African ethnobotany-poisons and drugs. Chapman and Hall, Weinheim. Germany. pp. 495–499

  16. Salam OA, Nada S (2011) Piracetam reverses haloperidol-induced catalepsy in mice. Turk J Med Sci 41(4):693–699

    Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to M. G. Magaji.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Magaji, M.G., Mohammed, M., Magaji, R.A. et al. Evaluation of the antipsychotic potential of aqueous fraction of Securinega virosa root bark extract in mice. Metab Brain Dis 29, 161–165 (2014). https://doi.org/10.1007/s11011-014-9483-x

Download citation

Keywords

  • Securinega virosa
  • Schizophrenia
  • Medicinal
  • Psychosis
  • Apomorphine
  • Catalepsy