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Current advances in human-induced pluripotent stem cell-based models and therapeutic approaches for congenital heart disease

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Abstract

Congenital heart disease (CHD) represents a significant risk factor with profound implications for neonatal survival rates and the overall well-being of adult patients. The emergence of induced pluripotent stem cells (iPSCs) and their derived cells, combined with CRISPR technology, high-throughput experimental techniques, and organoid technology, which are better suited to contemporary research demands, offer new possibilities for treating CHD. Prior investigations have indicated that the paracrine effect of exosomes may hold potential solutions for therapeutic intervention. This review provides a summary of the advancements in iPSC-based models and clinical trials associated with CHD while elucidating potential therapeutic mechanisms and delineating clinical constraints pertinent to iPSC-based therapy, thereby offering valuable insights for further deliberation.

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Acknowledgements

We would like to acknowledge the hard and dedicated work of all the staff that implemented the intervention and evaluation components of the study.

Funding

National Natural Science Foundation of China (No.81300130). Science and Technology Projects for People’s Livelihood of Liaoning Province (2021JH/10300008). Provincial Natural Science Foundation Joint Fund of Liaoning (2023-BSBA-363). Basic Research Projects of Liaoning Province (JYTMS20230073).

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Author notes

  1. Meiling Cao and Yanshan Liu have contributed equally to this study.

Authors and Affiliations

  1. Department of Neonatology, The First Hospital of China Medical University, Shenyang, 110001, Liaoning, China

    Meiling Cao

  2. Department of Pediatrics, The First Hospital of China Medical University, No.155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, China

    Yanshan Liu, Ying Sun, Ruiyi Han & Hongkun Jiang

Authors
  1. Meiling Cao
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  2. Yanshan Liu
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  3. Ying Sun
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  4. Ruiyi Han
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  5. Hongkun Jiang
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Contributions

Conception and design of the research: Jiang HK, Cao ML. Acquisition of data: Liu YS. Analysis and interpretation of the data: Sun Y, Han RY. Statistical analysis: Sun Y, Han RY. Obtaining financing: Jiang HK. Writing of the manuscript: Cao ML, Liu YS. Critical revision of the manuscript for intellectual content: Cao ML, Jiang HK. All authors read and approved the final draft.

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Correspondence to Hongkun Jiang.

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This study is a literature review and does not require the informed consent of patients, and does not require ethical approval.

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Cao, M., Liu, Y., Sun, Y. et al. Current advances in human-induced pluripotent stem cell-based models and therapeutic approaches for congenital heart disease. Mol Cell Biochem (2024). https://doi.org/10.1007/s11010-024-04997-z

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