Abstract
Lipids are the key component of all membranes composed of a variety of molecules that transduce intracellular signaling and provide energy to the cells in the absence of nutrients. Alteration in lipid metabolism is a major factor for cancer heterogeneity and a newly identified cancer hallmark. Reprogramming of lipid metabolism affects the diverse cancer phenotypes, especially epithelial–mesenchymal transition (EMT). EMT activation is considered to be an essential step for tumor metastasis, which exhibits a crucial role in the biological processes including development, wound healing, and stem cell maintenance, and has been widely reported to contribute pathologically to cancer progression. Altered lipid metabolism triggers EMT and activates multiple EMT-associated oncogenic pathways. Although the role of lipid metabolism-induced EMT in tumorigenesis is an attractive field of research, there are still significant gaps in understanding the underlying mechanisms and the precise contributions of this interplay. Further study is needed to clarify the specific molecular mechanisms driving the crosstalk between lipid metabolism and EMT, as well as to determine the potential therapeutic implications. The increased dependency of tumor cells on lipid metabolism represents a novel therapeutic target, and targeting altered lipid metabolism holds promise as a strategy to suppress EMT and ultimately inhibit metastasis.
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Funding
This research work was supported by the National Key R&D Program of China (2022YFA1104002), the National Natural Science Foundation of China (Nos. 82373096, 82273480, 82002960, 82003141), Applied Basic Research Planning Project of Liaoning (2023JH2/101600019), the Science and Technology Talent Innovation Support Policy Implementation Program of Dalian-Outstanding young scientific and technological talents (2023RY013), and Dalian High-level Talents Innovation Support Program-Young Science and Technology Star (2021RQ004).
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ZUD reviewed the literature and drafted the manuscript. QL and FP conceived the work. BC and FP reviewed the literature and edited the manuscript. CW, XZ, and AM edited the manuscript. All authors approved the manuscript for submission.
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Din, Z.U., Cui, B., Wang, C. et al. Crosstalk between lipid metabolism and EMT: emerging mechanisms and cancer therapy. Mol Cell Biochem (2024). https://doi.org/10.1007/s11010-024-04995-1
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DOI: https://doi.org/10.1007/s11010-024-04995-1