Skip to main content
SpringerLink
Log in

RETRACTED ARTICLE: Tactics for treating young children with pyelonephritis and vesicoureteral reflux associated with impaired fibrillogenesis

  • Published:
Molecular and Cellular Biochemistry Aims and scope Submit manuscript

This article was retracted on 20 February 2024

This article has been updated

Abstract

The purpose of this study is to substantiate the choice and evaluate the effectiveness of therapeutic tactics aimed at suppressing collagen formation and improving metabolic processes in the kidney parenchyma in young children with pyelonephritis against the background of vesicoureteral reflux associated with undifferentiated tissue dysfunction. 67 children from 2 weeks to 3 years old with pyelonephritis and vesicoureteral reflux were examined. All children during the period of remission of the inflammatory process were examined for the content of oxyproline in the urine. Urine crystallinity and urinary excretion were determined, and markers of the morphofunctional state of the cytomembranes of the renal epithelium were determined: calcification test—the presence of polar lipids in the urine and test for the presence of lipid peroxidation products in the urine. Children with high urinary hydroxyproline excretion prior to protocol treatment of pyelonephritis during the remission of the inflammatory process at the stage of maintenance therapy were recommended to receive metabolic preparations that can inhibit collagen formation and improve parenchyma metabolic processes during the month—vitamin E 10% and l-carnitine in age-related doses. After 6 months, a study was made on the functional state of the renal parenchyma in the dynamics of treatment. After metabolic antihypoxic and membrane-protective therapy, there was a significant positive dynamic of all markers of tissue hypoxia and membrane destruction in the kidney parenchyma, which confirms the inhibition of collagen formation processes and a decrease in tissue hypoxia with vitamin E and l-carnitine in age-related doses.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Data availability

Enquiries about data availability should be directed to the authors.

Change history

References

  1. Kryganova TA, Dlin VV (2016) The frequency of anomalies of the urinary system and the functional state of the kidneys, depending on the severity of connective tissue dysplasia in children. Russ Bull Perinatol Pediatr 3:81–86

    Google Scholar 

  2. Povshedna TYu, Shevchuk DV, Korniychuk NM (2015) The role of timely treatment of congenital malformations of the urinary system in the prevention of chronic renal failure in children. Biol Res 1:423–429

    Google Scholar 

  3. Semyanchuk VB (2015) Prevalence of manifestations of undifferentiated connective tissue dysplasia in children of Prykarpattia, patients with bronchial asthma. Act Prob Mod Med 15(2):149–154

    Google Scholar 

  4. Lukina TS (2015) Evaluation of the oxyproline marker and its value in women with undifferentiated connective tissue dysplasia. Mod Med Top Issues 6–7(41):6–10

    Google Scholar 

  5. Maydannyk VH, Burlaka YeA (2015) The state of metabolic-hypoxic disorders in diabetic nephropathy in children. Exp Clin Physiol Biochem 4:47–55

    Article  Google Scholar 

  6. Averyanova NI, Balueva LG (2012) Oxalate crystalluria in children. Int J Appl Fund Res 5:25–27

    Google Scholar 

  7. Kens KA (2012) Non-invasive markers of renal dysfunction in young children with vesicoureteral reflux in the dynamics of surgical and metabolic treatment. Institute of Urology of the National Academy of Medical Sciences of Ukraine, Kyiv

    Google Scholar 

  8. Lukyanova LD (2013) Signal role of mitochondria in adaptation to hypoxia. Physiol J 59(6):141–154

    CAS  Google Scholar 

  9. Topchiy II, Kyryenko AN, Bondar TN, Lesovaya AV, Shchenyavskaya EN (2012) Lipid peroxidation and nitric oxide metabolism in patients with chronic kidney disease in the dynamics of treatment. Ukrainian J Nephrol Dial 1:3–8

    Google Scholar 

  10. Gubergrits NB, Golubova OA, Lukashevich GM (2012) l-Carnitine: from biochemical properties to clinical use. Mod Gastroenterol 2:114–121

    Google Scholar 

  11. Butolin EG, Chernyshova TE, Ivanova IL, Malkova AA, Pelin AI, Soloviev AA, Ovchinnikova EI, Shklyaeva LA (2012) Neurological aspects of connective tissue dysplasia: diagnosis, treatment, rehabilitation. Izhevsk State Medical Academy of Roszdrav, Izhevsk

    Google Scholar 

  12. Nagornaya NV, Chetverik NA (2010) Oxidative stress: impact on the human body, assessment methods. Child Health 2:140–145

    Google Scholar 

  13. Order of the Ministry of Health of Ukraine No. 627 “On approval of the protocol for the treatment of children with urinary tract infections and tubolointerstitial nephritis” (2008). https://zakon.rada.gov.ua/rada/show/v0627282-08#Text

  14. Order of the Ministry of Health of Ukraine No. 140 “On amendments to the order of the Ministry of Health of Ukraine” (2008). https://zakon.rada.gov.ua/rada/show/v0140282-08#Text

  15. Nyankovskyy SL, Dobryk OO, Iskiv MYu (2014) Patent No. 95526 “Method for diagnosing connective tissue dysplasia.” Danylo Halytsky Lviv National Medical University, Lviv

    Google Scholar 

  16. Lukianenko NS, Hnateyko OZ, Kech NR, Pechenyk SO, Chaykovska HS, Kovaliv IB, Vishtak NV (2012) Algorithm for diagnosis and medical and genetic counseling of ecologically determined pathology in children living permanently in conditions of high concentrations of heavy metal salts and fluorine. National Academy of Medical Sciences of Ukraine, Kyiv

    Google Scholar 

  17. Nikitina NA, Starets YeA, Kalashnikova YeA, Galich SR, Sochinskaya TV (2013) Congenital anomalies in the number of kidneys: frequency, etiopathogenesis, prenatal diagnosis, clinical picture, physical development, diagnosis, treatment, prevention (part 1). Child Health 6(49):107–111

    Article  Google Scholar 

  18. Kryganova TA, Aksenova MYe, Dlin VV (2016) Vesicoureteral reflux and its complications in children depending on the severity of connective tissue dysplasia. Russ Bull Perinatol Pediatr 4:93–97

    Google Scholar 

  19. Martynov AI, Nechayeva GI, Akatova YeV, Vershinina MV, Viktorova IA, Gromova OA, Drokina OV, Druk IV, Dubiley GS, Ilinykh AA, Kudinova YeG, Lisichenko OV, Loginova YeN, Lyalyukova YeA, Nagayeva TA, Nadey YeV, Plotnikova OV, Ponomareva DA (2016) National recommendations of the Russian scientific medical society of physicians for the diagnosis, treatment and rehabilitation of patients with connective tissue dysplasia. Med Bull North Cauc 1:2–76

    Google Scholar 

  20. Molcan J, Dobrovanov A, Koren R, Kralinsky K, Balaz V (2021) Unilateral scrotal hernia with dual ureter herniation: The first experience of successful surgical correction. Pediat - Zh im G.N. Speranskogo 100(4):171–75

  21. Dobrovanov O, Kralinsky K, Molcan J, Kovalchuk VP (2019) Relevance of ultrasound neonatal screening of the urinary system. Ross Vest Perinatol i Ped 64(2):68–72. https://doi.org/10.21508/1027-4065-2019-64-3-68-72

Download references

Funding

The authors have not disclosed any funding.

Author information

Authors and Affiliations

  1. Department of Clinical Genetics, Institute of Hereditary Pathology of the National Academy of Medical Sciences of Ukraine, 31a M. Lysenko Str., Lviv, 79008, Ukraine

    Nataliia Lukyanenko

  2. Department of Propaedeutics of Pediatrics and Medical Genetics, Danylo Halytsky Lviv National Medical University, 69 Pekarska Str., Lviv, 79010, Ukraine

    Nataliia Lukyanenko

  3. Department of Bioorganic and Biological Chemistry and Clinical Biochemistry, Bukovinian State Medical University, 2 Teatralnaya Sq., Chernivtsi, 58002, Ukraine

    Evelina Lenha

  4. College of Medicine, Ajman University, University Str., Al-Jurf, Ajman, United Arab Emirates

    Anastasiya Spaska

  5. Center of Medical and Bio-allied Health Sciences Research, Ajman University, University Str., Al-Jurf, Ajman, United Arab Emirates

    Anastasiya Spaska

  6. Department of Pediatrics No. 4, Bogomolets National Medical University, 13 Taras Shevchenko Blvd., Kyiv, 01601, Ukraine

    Tetiana Klets & Tetiana Shevchenko

Authors
  1. Nataliia Lukyanenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Evelina Lenha
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anastasiya Spaska
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tetiana Klets
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tetiana Shevchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nataliia Lukyanenko.

Ethics declarations

Conflict of interest

All authors state they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. A study was approved by National Ethics Commission of the Ministry of Health of the Ukraine.

Consent to participate

The parents of all study participants gave written consent to participate.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article has been retracted. Please see the retraction notice for more detail:https://doi.org/10.1007/s11010-024-04963-9

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lukyanenko, N., Lenha, E., Spaska, A. et al. RETRACTED ARTICLE: Tactics for treating young children with pyelonephritis and vesicoureteral reflux associated with impaired fibrillogenesis. Mol Cell Biochem 478, 531–538 (2023). https://doi.org/10.1007/s11010-022-04529-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11010-022-04529-7

Keywords

Search

Navigation