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The role of short-chain fatty acids in central nervous system diseases

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Abstract

Previous studies have found that intracorporal short-chain fatty acids (SCFAs), as the main metabolites of the gut microbiota, play important roles in the intestinal physiology and immune function. Along with the in-depth study of the brain-gut axis, the attention to the roles of SCFAs in central nervous system (CNS) has been raised. It has been found that SCFAs function in CNS diseases by regulating inflammatory response, neuronal apoptosis, oxidative stress, the integrity of the blood–brain barrier (BBB) and so on. Here, the changes, the effects and the mechanisms of different SCFA as individual or mixture in different CNS diseases were summarized. It is expected to lead to increased interest in SCFAs studies as an important regulator in CNS diseases and provide feasible suggestions based on SCFAs for the therapy of CNS diseases in the future.

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Funding

This study was supported by National Natural Science Foundation of China (82171429).

Author information

Authors and Affiliations

  1. Wuxi Medical School, Jiangnan University, Wuxi, 214122, Jiangsu, China

    Yin Dong & Chun Cui

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  1. Yin Dong
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  2. Chun Cui
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YD contributed to writing and revision of the manuscript. Professor CC provided valuable comments for manuscript revision.

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Correspondence to Chun Cui.

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Dong, Y., Cui, C. The role of short-chain fatty acids in central nervous system diseases. Mol Cell Biochem 477, 2595–2607 (2022). https://doi.org/10.1007/s11010-022-04471-8

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