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Association of sirtuins (SIRT1-7) with lung and intestinal diseases

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Abstract

“Exterior-interior correlation between the lung and large intestine” is one of the important contents of traditional Chinese medicine. This theory describes the role of the lung and the intestine in association with disease treatment. The “lung-gut” axis is a modern extension of the “exterior-interior correlation between lung and large intestine” theory in TCM. Sirtuin (SIRT) is a nicotinamide adenine dinucleotide (NAD+)-dependent enzyme family with deacetylase properties, which is highly conserved from bacteria to humans. The sirtuin defines seven silencing regulatory proteins (SIRT1-7) in human cells. It can regulate aging, metabolism, and certain diseases. Current studies have shown that sirtuins have dual characteristics, acting as both tumor promoters and tumor inhibitors in cancers. This paper provides a comparative summary of the roles of SIRT1-7 in the intestine and lung (both inflammatory diseases and tumors), and the promoter/suppressor effects of targeting SIRT family microRNAs and modulators of inflammation or tumors. Sirtuins have great potential as drug targets for the treatment of intestinal and respiratory diseases. Meanwhile, it may provide new ideas of future drug target research.

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Funding

This work was financially supported by National Natural Science Foundation of China (Grant Nos. U1903122, 81872768), Liaoning Revitalization Talents Program (XLYC1807118), Shenyang Young Scientific and Technological Innovators Program (RC200408), The Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China (P2020-KF01), State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) (CMEMR2021-B01), Educational Committee Foundation of Liaoning Province (2020LJC09), Doctoral Scientific Research Foundation of Liaoning Province (2020-BS-129) and Special Fund of Research Institute of Drug Regulatory Science Research Shenyang Pharmaceutical University (2021jgkx010).

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  1. Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang, 110016, People’s Republic of China

    Yuhan Chen, Di Zhou, Yuan Feng, Bingxin Li, Yong Cui, Gang Chen & Ning Li

  2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China

    Gang Chen

  3. Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, China

    Gang Chen

  4. School of Medical Device, Shenyang Pharmaceutical University, Shenyang, China

    Yong Cui

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YC performed the literature search and wrote the manuscript. GC and NL conceived and designed the review. YC helped consult new references and revise the manuscript. DZ, YF, and BL critically reviewed the manuscript. All authors approved the final manuscript for publication.

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Chen, Y., Zhou, D., Feng, Y. et al. Association of sirtuins (SIRT1-7) with lung and intestinal diseases. Mol Cell Biochem 477, 2539–2552 (2022). https://doi.org/10.1007/s11010-022-04462-9

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