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Non-coding RNA: insights into the mechanism of methamphetamine neurotoxicity

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Abstract

Chronic exposure of the methamphetamine has been shown to lead to neurotoxicity in rodents and humans. The manifestations of methamphetamine neurotoxicity include methamphetamine use disorder, methamphetamine abuse, methamphetamine addiction and methamphetamine behavioral sensitization. Repeated use of methamphetamine can cause methamphetamine use disorder. The abuse and addiction of methamphetamine are growing epidemic worldwide. Repeated intermittent exposure to methamphetamine can cause behavioral sensitization. In addition, many studies have shown that changes in the expression of non-coding RNA in the ventral tegmental area and nucleus accumbens will affect the behavioral effects of methamphetamine. Non-coding RNA plays an important role in the behavioral effects of methamphetamine. Therefore, it is important to study the relationship between methamphetamine and non-coding RNA. The purpose of this review is to study the non-coding RNA associated with methamphetamine neurotoxicity to search for the possible therapeutic target of the methamphetamine neurotoxicity.

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Funding

This review was funded by National Natural Science Foundation of China (No. 81973404, 81503058); Department of Education of Liaoning Province (No. JC2019034); and Natural Science Foundation of Liaoning Province (No. 2014021065).

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  1. Department of Clinical Pharmacology, School of Pharmacy, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, People’s Republic of China

    Ying-Jian Gu, Lei Chen, Lin Cheng, Ming-Yuan Zhou & Yun Wang

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Gu, YJ., Chen, L., Cheng, L. et al. Non-coding RNA: insights into the mechanism of methamphetamine neurotoxicity. Mol Cell Biochem 476, 3319–3328 (2021). https://doi.org/10.1007/s11010-021-04160-y

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