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The possible role of sirtuins in male reproduction

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Abstract

Global influence of male infertility is increasing in recent decades. Proper understanding of genetics, anatomy, physiology and the intricate interrelation of male reproductive system are much needed for explaining the etiology of male infertility; and a detailed study on the epigenetics, indeed, will reveal the molecular mechanism behind its etiology. Sirtuins, the molecular sensors, are NAD+ dependent histone deacetylases and ADP- ribosyl transferases, participate in the chief events of epigenetics. In mammals, sirtuin family comprises seven members (SIRT1-SIRT7), and they all possess a conserved NAD+ binding catalytic domain, termed the sirtuin core domain which is imperative for their activity. Sirtuins exert a pivotal role in cellular homeostasis, energy metabolism, apoptosis, age-related disorders and male reproductive system. However, their exact role in male reproduction is still obscure. This article specifically reviews the role of mammalian sirtuins in male reproductive function, thereby, prompting further research to discover the restorative methods and its implementation in reproductive medicine.

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Abbreviations

StAR:

Steroidogenic acute regulatory protein

DNMT:

DNA (cytosine-5) methyl transferases

HMTases:

Histone methyltransferases

SUMO:

Small ubiquitin-related modifier

HAT:

Histone acetyl transferases

HDAC:

Histone deacetylases

TSA:

Trichostatin A

Mnase:

Micrococcal nuclease

Brdt:

Bromodomain testis-specific protein

DFI:

DNA Fragmentation Index

Sir2 protein:

Silent information regulator protein

MEF:

Mouse embryonic fibroblasts

PCNA:

Proliferating cell nuclear antigen

TAU:

Triton, acetic acid, and urea

HKMT:

Histone lysine methyl transferase

KO:

Knockout

NDAC:

NAD-dependent deacetylase activity

ROS:

Reactive oxygen species

FISH:

Fluorescence in situ hybridization

MnSOD:

Manganese superoxide dismutase

NHEJ:

Nonhomologous end joining

DSB:

Double strand breaks

HPA:

Hypothalamus–pituitary–adrenal

HPT:

Hypothalamus-pituitary-thyroid

HPG:

Hypothalamus-pituitary–Gonadal

Polk:

DNA polymerase-kappa

GnRH:

Gonadotropin releasing hormone

LH:

Luteinizing hormone

FSH:

Follicle stimulating hormone

GO:

Gene Ontology

SF1:

Steroidogenic factor 1

CASA:

Computer-assisted semen analysis

Sp 56:

Sperm protein 56

LC3:

Microtubule-associated protein 1A/1B-light chain 3

OAT:

Oligoasthenoteratozoospermia

BPA:

Bisphenol A

AR:

Androgen receptor

ARKO:

Androgen receptor knockout

SCARKO:

Sertoli Cell-selective androgen receptor knockout

HFD:

High fat diet

CD:

Control diet

APRT:

Adenine phosphoribosyltransferase

HU:

Hydroxyurea

LPS:

Lipopolysaccharide

17β-HSD:

17β–Hydroxysteroid dehydrogenase

AMPK:

AMP-activated protein kinase

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Acknowledgements

CP acknowledges Department of Science and Technology (DST)—Science and Engineering Research Board (SERB) for the financial assistance (EMR/2017/003670). And also acknowledges RUSA-MHRD, DST-PURSE and DST-FIST for the infrastructure provided to the Department of Biochemistry, Bharathidasan University. AK acknowledges the financial assistance as Senior Research Fellowship (RBMH/FW/2018/13) from Indian Council for Medical Research (ICMR), New Delhi and LFMA gratefully acknowledges financial assistance from Department of Science and Technology (DST)—Innovation in Science Pursuit for Inspired Research (INSPIRE).

Funding

CP acknowledges Department of Science and Technology (DST)—Science and Engineering Research Board (SERB) for the financial assistance (EMR/2017/003670).

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Authors and Affiliations

  1. Molecular Endocrinology Laboratory, Department of Biochemistry, Centre for Excellence in Life Sciences, Bharathidasan University, Tiruchirappalli, 620 024, India

    Chithra Loganathan, Arun Kannan, Antojenifer Panneerselvam, Lezy Flora Mariajoseph-Antony & Chidambaram Prahalathan

  2. Centre for Biotechnology, Anna University, Chennai, 600 025, India

    Sekar Ashok Kumar

  3. Microbial Biotechnology Laboratory, Department of Marine Biotechnology, Bharathidasan University, Tiruchirappalli, 620 024, India

    Kumarasamy Anbarasu

  4. Molecular Endocrinology Laboratory, Department of Biochemistry, Centre for Excellence in Life Sciences, Bharathidasan University, Tiruchirappalli, 620 024, India

    Chidambaram Prahalathan

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  5. Sekar Ashok Kumar
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Contributions

CL: Conceptualization and initial draft. CP: Design and supervision. CL, CP, SAK, KA, AK, AP, LFMA: Critical revision and suggestions. All authors discussed and approved the final manuscript.

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Correspondence to Chidambaram Prahalathan.

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Loganathan, C., Kannan, A., Panneerselvam, A. et al. The possible role of sirtuins in male reproduction. Mol Cell Biochem 476, 2857–2867 (2021). https://doi.org/10.1007/s11010-021-04116-2

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