Abstract
DNA hydroxymethylation plays a very important role in some biological processes, such as DNA methylation process. In addition, its presence can also cause some diseases. In this paper, the electrical properties of cytosine hydroxymethylated (Chm) DNA sequences are studied. The density functional theory (DFT) and Landauer–Büttiker framework are used to study the decoherence conductance and transmission of the Chm strands in different configurations, which provides a theoretical basis for the detection of Chm. The results show that the conductance of the hydroxymethylated DNA strand is smaller than that of the native and methylated strands. The length dependence of the Chm strands is also studied. With the length increasing, the conductance becomes larger. This study shows that DNA methylation can be detected electrically.
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The data used to support the funding of this study are included within the article. The data and materials in the current study are available from the corresponding author on reasonable requests.
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Funding
This work was supported by the China Scholarship Council Study Program for Young Backbone Teachers under Grant No. 201707845017, the National Nature Science Foundation of China under Grant No. 61804020, the Scientific and Technological Research Foundation of Chongqing Municipal Education Commission under Grant No. KJQN201900643, the Raised Fund Plan of National Natural Science Foundation of China of Chongqing University of Posts and Telecommunications under Grant No. A2016-143, the PhD scientific research foundation of Chongqing University of Posts and Telecommunications under Grant Nos. A2015-11 and A2015-12, and SR Patil’s support from SERB, India under Grant No. TAR/2018/001188.
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He, L., Zhang, J., He, C. et al. Effect of cytosine hydroxymethylation on DNA charge transport. Mol Cell Biochem 476, 1599–1603 (2021). https://doi.org/10.1007/s11010-020-03957-7
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DOI: https://doi.org/10.1007/s11010-020-03957-7