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Biochemical interaction of salt sensitivity: a key player for the development of essential hypertension

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Abstract

Worldwide, more than 1 billion people have elevated blood pressure, with up to 45% of adults affected by the disease. In 2016 the global health study report on patients from 67 countries was released in Lancet, which identified hypertension as the world’s leading cause for death and disability-adjusted years since 1990. This paper aims to analyze the pathophysiological connection between hemodynamic inflammatory reactions through sodium balance, salt sensitivity, and potential pathophysiological reactions. Besides, we explore how sodium consumption enhances the expression of transient receptor potential channel 3 (TrpC3) mRNA and facilitates the release of calcium inside immune cell groups, together with elevated blood pressure in essential hypertensive patients.

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

    Imran Kazmi & Fahad A. Al-Abbasi

  2. Department of Pharmacology, College of Pharmacy, Umm Al Qura University, Mecca, Saudi Arabia

    Waleed Hassan Al-Maliki

  3. Faculty of Medicine, Ala-Too International University, 720048, Bishkek, Kyrgyzstan

    Haider Ali

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  1. Imran Kazmi
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Kazmi, I., Al-Maliki, W.H., Ali, H. et al. Biochemical interaction of salt sensitivity: a key player for the development of essential hypertension. Mol Cell Biochem 476, 767–773 (2021). https://doi.org/10.1007/s11010-020-03942-0

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