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The emerging roles of circular RNAs in regulating the fate of stem cells

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Abstract

Circular RNAs(circRNAs) are a large family of RNAs shaping covalently closed ring-like molecules and have become a hotspot with thousands of newly published studies. Stem cells are undifferentiated cells and have great potential in medical treatment due to their self-renewal ability and differentiation capacity. Abundant researches have unveiled that circRNAs have unique expression profile during the differentiation of stem cells and could serve as promising biomarkers of these cells. There are key circRNAs relevant to the differentiation, proliferation, and apoptosis of stem cells with certain mechanisms such as sponging miRNAs, interacting with proteins, and interfering mRNA translation. Moreover, several circRNAs have joined in the interplay between stem cells and lymphocytes. Our review will shed lights on the emerging roles of circRNAs in regulating the fate of diverse stem cells.

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Funding

This work was financially supported by grants from the National Natural Science Foundation of China (No. 81700938, 81670957, and 81772876) and the Beijing Natural Science Foundation (No. 7172239).

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  1. Department of Orthodontics, Peking University School and Hospital of Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing, 100081, People’s Republic of China

    Ziyao Zhuang, Weiran Li & Yunfei Zheng

  2. Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, People’s Republic of China

    Lingfei Jia

  3. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, 100081, People’s Republic of China

    Lingfei Jia

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  1. Ziyao Zhuang
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  2. Lingfei Jia
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  4. Yunfei Zheng
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ZZ drafted the paper, performed the literature search, and analyzed data. LJ had the idea for the article. YZ and WL revised the paper and contributed equally to this manuscript.

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Zhuang, Z., Jia, L., Li, W. et al. The emerging roles of circular RNAs in regulating the fate of stem cells. Mol Cell Biochem 476, 231–246 (2021). https://doi.org/10.1007/s11010-020-03900-w

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