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Overexpression of ARNT2 is associated with decreased cell proliferation and better prognosis in gastric cancer

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Abstract

Aryl hydrocarbon-receptor nuclear translocator (ARNT2) is a member of the bHLH PAS (basic helix–loop–helix Period/ARNT/Single-minded) family of transcription factors. Recently, some studies indicate that ARNT2 is associated with the occurrence and development of carcinoma. However, its roles in gastric cancer (GC) remain unclear. In the present study, we found that ARNT2 expression level is lower in GC tissues compared with adjacent non-tumor tissues, and negatively correlated with depth of invasion of the tumor, differentiated degree, and poor survival of GC patients. Overexpression of ARNT2 inhibits cell proliferation. Furthermore, AKT pathway contributed to ARNT2 -mediated PC proliferation. Taken together, our results provide the first evidence that high expression of ARNT2 inhibited proliferation of GC cells and affected tumor aggressiveness in GC patients.

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (No. 31671468 and 81602593), the Chinese Postdoctoral Science Foundation (No. 2016M602152), the Shandong Provincial Natural Science Foundation of China (No. 2016ZRA01062, ZR2015HM018, ZR2017MH071, and ZR2012HM061), and the Jinan Postdoctoral Innovation Project (172634).

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Author notes

  1. Yanfei Jia and Shuhua Hao have contributed equally to this work.

Authors and Affiliations

  1. Central Laboratory, Jinan Central Hospital Affiliated to Shandong University, 250013, Jinan, People’s Republic of China

    Yanfei Jia, Xiaoli Ma, Yan Zheng, Dongjie Xiao & Yunshan Wang

  2. Genetic laboratory, Women and Children’s Health Care Hospital of Linyi, 276000, Linyi, People’s Republic of China

    Shuhua Hao

  3. Department of Breast Surgery, Jinan Central Hospital Affiliated to Shandong University, 250013, Jinan, People’s Republic of China

    Guangchao Jin

  4. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, 250021, Jinan, People’s Republic of China

    Hongyu Li

  5. Shandong Province Key Lab of Tumor Target Molecule, Jinan Central Hospital Affiliated to Shandong University, 250013, Jinan, People’s Republic of China

    Yunshan Wang

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  1. Yanfei Jia
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  2. Shuhua Hao
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  3. Guangchao Jin
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  4. Hongyu Li
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Correspondence to Dongjie Xiao or Yunshan Wang.

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Jia, Y., Hao, S., Jin, G. et al. Overexpression of ARNT2 is associated with decreased cell proliferation and better prognosis in gastric cancer. Mol Cell Biochem 450, 97–103 (2019). https://doi.org/10.1007/s11010-018-3376-y

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  • DOI: https://doi.org/10.1007/s11010-018-3376-y

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