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Molecular and Cellular Biochemistry

, Volume 442, Issue 1–2, pp 59–72 | Cite as

Repetitive transcranial magnetic stimulation inhibits Sirt1/MAO-A signaling in the prefrontal cortex in a rat model of depression and cortex-derived astrocytes

  • Zheng-wu Peng
  • Fen Xue
  • Cui-hong Zhou
  • Rui-guo Zhang
  • Ying Wang
  • Ling Liu
  • Han-fei Sang
  • Hua-ning Wang
  • Qing-rong Tan
Article
  • 353 Downloads

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a useful monotherapy for depression or adjunctive therapy for resistant depression. However, the anti-depressive effects of different parameters and the underlying mechanisms remain unclear. Here, we aimed to assess the effect of rTMS with different parameters (1/5/10 Hz, 0.84/1.26 T) on the depressive-like behaviors, 5-hydroxytryptamine (5-HT), 5-HIAA (5-hydroxyindoleacetic acid) and DA and NE levels, and monoamine oxidase A (MAO-A) activity in chronic unpredictable stress-treated rats, along with the expression of sirtuin 1 (Sirt1) and MAO-A in the prefrontal cortex (PFC) and cortex-derived astrocytes from new-born rats. Moreover, the depressive-like behaviors were monitored following the transcranial injection of the Sirt1 inhibitor EX527 (1 mM) daily for 1 week. We found that rTMS treatment (5/10 Hz, 0.84/1.26 T) ameliorated depressive-like behaviors, increased 5-HT, DA and NE levels, decreased the 5-HIAA level and Sirt1 and MAO-A expression, and reduced MAO-A activity in the PFC. The depressive-like behaviors were also ameliorated after the transcranial injection of EX527. Importantly, rTMS (5/10 Hz, 0.84/1.26 T) inhibited Sirt1 and MAO-A expressions in astrocytes and Sirt1 knockdown with short hairpin RNA decreased MAO-A expression in astrocytes. These results suggest that the inhibition of Sirt1/MAO-A expression in astrocytes in the PFC may contribute to the different anti-depressive effects of rTMS with different parameters, and may also provide a novel insight into the mechanisms underlying major depressive disorder.

Keywords

rTMS CUS Astrocytes Sirt1/MAO-A 

Abbreviations

rTMS

Repetitive transcranial magnetic stimulation

rMS

Repetitive magnetic stimulation

CUS

Chronic unpredictable stress

MDD

Major depressive disorder

5-HT

5-Hydroxytryptamine

5-HIAA

5-Hydroxyindoleacetic acid

Sirt1

Sirtuin 1

MAO-A

Monoamine oxidase A

MAO-B

Monoamine oxidase B

SPT

Sucrose preference test

FST

Forced swimming test

OFT

Open-field test

NE

Norepinephrine

DA

Dopamine

PFC

Prefrontal cortex

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation (Grant Nos.: 81401109, 81401019, 81371478, 81571309, 81671343 and 81630032) of China. The funding sources had no role in the planning, conduct, or publication of this work.

Compliance with ethical standards

Conflict of interest

All authors declare that they have no any conflict of interest in this study.

Supplementary material

11010_2017_3193_MOESM1_ESM.jpg (818 kb)
Supplementary material 1 (JPEG 818 kb)

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Zheng-wu Peng
    • 1
  • Fen Xue
    • 1
  • Cui-hong Zhou
    • 1
  • Rui-guo Zhang
    • 1
  • Ying Wang
    • 1
  • Ling Liu
    • 2
  • Han-fei Sang
    • 3
  • Hua-ning Wang
    • 1
  • Qing-rong Tan
    • 1
  1. 1.Department of Psychiatry, Xijing HospitalFourth Military Medical UniversityXi’anChina
  2. 2.Institute of NeuroscienceFourth Military Medical UniversityXi’anChina
  3. 3.Department of Anesthesiology, Xijing HospitalFourth Military Medical UniversityXi’anChina

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