Phenotypic and genotypic characterization of antioxidant enzyme system in human population exposed to radiation from mobile towers

Molecular and Cellular Biochemistry volume 440, pages1–9(2018)Cite this article

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Abstract

In the present era, cellular phones have changed the life style of human beings completely and have become an essential part of their lives. The number of cell phones and cell towers are increasing in spite of their disadvantages. These cell towers transmit radiation continuously without any interruption, so people living within 100s of meters from the tower receive 10,000 to 10,000,000 times stronger signal than required for mobile communication. In the present study, we have examined superoxide dismutase (SOD) enzyme activity, catalase (CAT) enzyme activity, lipid peroxidation assay, and effect of functional polymorphism of SOD and CAT antioxidant genes against mobile tower-induced oxidative stress in human population. From our results, we have found a significantly lower mean value of manganese superoxide dismutase (MnSOD) enzyme activity, catalase (CAT) enzyme activity, and a high value of lipid peroxidation assay in exposed as compared to control subjects. Polymorphisms in antioxidant MnSOD and CAT genes significantly contributed to its phenotype. In the current study, a significant association of genetic polymorphism of antioxidant genes with genetic damage has been observed in human population exposed to radiations emitted from mobile towers.

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Acknowledgements

We are thankful to the Science and Engineering Research Board, Department of Science and Technology (DST), New Delhi, India for funding through Grant No. SR/FT/LS-146/2011 and to all blood donors for their voluntary participation in our study.

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Affiliations

  1. Department of Biotechnology, Kurukshetra University, Kurukshetra, Haryana, 136119, India

    Sachin Gulati, Anita Yadav, Neeraj Kumar & Kanu Priya

  2. Department of Biochemistry, Kurukshetra University, Kurukshetra, Haryana, 136119, India

    Sachin Gulati & Ranjan Gupta

  3. Department of Microbiology, Kurukshetra University, Kurukshetra, Haryana, 136119, India

    Neeraj K. Aggarwal

Authors
  1. Sachin Gulati
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  2. Anita Yadav
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  5. Neeraj K. Aggarwal
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  6. Ranjan Gupta
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Correspondence to Ranjan Gupta.

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The research protocol was approved by the institutional human ethics committee of Kurukshetra University, Kurukshetra (Haryana).

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Gulati, S., Yadav, A., Kumar, N. et al. Phenotypic and genotypic characterization of antioxidant enzyme system in human population exposed to radiation from mobile towers. Mol Cell Biochem 440, 1–9 (2018). https://doi.org/10.1007/s11010-017-3150-6

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Keywords

  • Antioxidant gene polymorphism
  • Electromagnetic fields (EMFs)
  • Mobile tower base stations
  • Oxidative stress
  • Reactive oxygen species