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Molecular and Cellular Biochemistry

, Volume 436, Issue 1–2, pp 79–86 | Cite as

CREB1 regulates glucose transport of glioma cell line U87 by targeting GLUT1

Article

Abstract

Glioma is stemmed from the glial cells in the brain, which is accounted for about 45% of all intracranial tumors. The characteristic of glioma is invasive growth, as well as there is no obvious boundary between normal brain tissue and glioma tissue, so it is difficult to resect completely with worst prognosis. The metabolism of glioma is following the Warburg effect. Previous researches have shown that GLUT1, as a glucose transporter carrier, affected the Warburg effect, but the molecular mechanism is not very clear. CREB1 (cAMP responsive element-binding protein1) is involved in various biological processes, and relevant studies confirmed that CREB1 protein regulated the expression of GLUT1, thus mediating glucose transport in cells. Our experiments mainly reveal that the CREB1 could affect glucose transport in glioma cells by regulating the expression of GLUT1, which controlled the metabolism of glioma and affected the progression of glioma.

Keywords

Glioma CREB1 GLUT1 pCREB1 Glucose transport 

Notes

Acknowledgements

This research was supported by the Chinese National Natural Science Foundation (Grant Nos. 31571171, 31600867, and 31100838), the Shanghai Natural Science Foundation (Grant No. 15ZR1414900), the Key Laboratory of Medical Electrophysiology (Southwest Medical University) of Ministry of Education of China (Grant No. 201502), and the Young Teachers of Shanghai Universities Training Program.

Supplementary material

11010_2017_3080_MOESM1_ESM.pdf (85 kb)
Supplementary material 1 (PDF 85 kb)

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.School of Life SciencesShanghai UniversityShanghaiPeople’s Republic of China

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