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Kidney injury molecule-1 (KIM-1) mediates renal epithelial cell repair via ERK MAPK signaling pathway

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Abstract

The expression of kidney injury molecule-1 (KIM-1), a very promising sensitive and specific urinary biomarker for acute renal injury, is markedly upregulated in injured and regenerating renal proximal tubular epithelial cells following ischemic or toxic insults, suggesting a possible role for this molecule in renal repair process. In the present study, we report that expression of KIM-1 facilitates renal tubular epithelial cell repair by promoting cell migration and proliferation. KIM-1 expression also enhances ERK MAPK activation, and the modulatory effect of KIM-1 on cellular repair process is likely mediated via ERK MAPK signaling pathway.

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Acknowledgments

This study was supported by Individual National Research Service Award 1F32DK10126 from National Institute of Health to Z. Zhang, and Institutional Research Fund from VA Loma Linda healthcare system and Loma Linda Veterans Association for Research for Research & Education. We are grateful to Amy Parker and Andrew Franklin for excellent technical assistances.

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, VA Loma Linda Healthcare System (111 N) and Loma Linda University School of Medicine, 11201 Benton Street, Loma Linda, CA, 92357, USA

    Zhiwei Zhang

  2. Division of Gastroenterology, Department of Medicine, VA Loma Linda Healthcare System and Loma Linda University School of Medicine, Loma Linda, CA, USA

    Cindy X. Cai

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  1. Zhiwei Zhang
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  2. Cindy X. Cai
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Correspondence to Zhiwei Zhang.

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Zhang, Z., Cai, C.X. Kidney injury molecule-1 (KIM-1) mediates renal epithelial cell repair via ERK MAPK signaling pathway. Mol Cell Biochem 416, 109–116 (2016). https://doi.org/10.1007/s11010-016-2700-7

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  • DOI: https://doi.org/10.1007/s11010-016-2700-7

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