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Malonyldialdehyde and glyoxal act differently on low-density lipoproteins and endotheliocytes

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Abstract

Under some pathological conditions, the natural dicarbonyl compounds can accumulate in the blood. The examples are malonyldialdehyde (MDA) formed as a secondary product of lipid peroxidation of unsaturated fatty acids during atherosclerosis, and glyoxal (GOX), a homolog of MDA, which accumulates during glucose autoxidation in patients with diabetes mellitus. This study compared the influence of both dicarbonyl compounds on low-density lipoproteins (LDL) and the membrane of endotheliocytes. In comparison with GOX, MDA induced more pronounced changes in physical and chemical properties of LDL particles. On the other hand, GOX-modified LDL particles were more prone to oxidation and aggregation than MDA-modified LDL. Incubation of endotheliocytes with MDA increased cell mechanical stiffness in contrast to incubation with GOX, which decreased it.

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Abbreviations

EC:

Endothelial cell

LDL:

Low density lipoproteins

MDA:

Malonyldialdehyde

GOX:

Glyoxal

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Acknowledgments

This work was supported by the Russian Foundation for Basic Research [Grant No. 13-04-01092].

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Authors and Affiliations

  1. Russian Cardiology Research Center, 3rd Cherepkovskaya Str., 15A, Moscow, 121552, Russia

    Elena M. Kumskova, Olga A. Antonova, Sergey A. Balashov, Alla K. Tikhaze, Arthur M. Melkumyants & Vadim Z. Lankin

  2. Chair of Physics of Living Systems, Moscow Institute of Physics and Technology (State University), Moscow, Russia

    Arthur M. Melkumyants

Authors
  1. Elena M. Kumskova
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  2. Olga A. Antonova
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  3. Sergey A. Balashov
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  4. Alla K. Tikhaze
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  5. Arthur M. Melkumyants
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  6. Vadim Z. Lankin
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Correspondence to Elena M. Kumskova.

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Kumskova, E.M., Antonova, O.A., Balashov, S.A. et al. Malonyldialdehyde and glyoxal act differently on low-density lipoproteins and endotheliocytes. Mol Cell Biochem 396, 79–85 (2014). https://doi.org/10.1007/s11010-014-2144-x

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  • DOI: https://doi.org/10.1007/s11010-014-2144-x

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