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TRAF4 participates in Wnt/β-catenin signaling in breast cancer by upregulating β-catenin and mediating its translocation to the nucleus

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Abstract

Tumor necrosis factor receptor-associated factor 4 (TRAF4) is upregulated in various subtypes of breast cancers and cell lines; however, the precise functions of TRAF4 are poorly understood. Our objective was to investigate its relationship with β-catenin. TRAF4 participates in several signaling pathways, such as NF-κB and JNK signaling pathways. In this study, we identified β-catenin as a TRAF4-binding protein, have shown that TRAF4 enhanced expression of β-catenin, and found that TRAF4 mediated the translocation of β-catenin from the cytoplasm to the nucleus, thereby facilitating activation of the Wnt signaling pathway in breast cancer.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, North 2nd Road 92, Heping Ward, 110001, Shenyang, China

    Ailian Wang, Jian Wang, Huanyan Ren, Fan Yang, Lili Sun, Kexin Diao, Zhijuan Zhao, Min Song, Enhua Wang & Xiaoyi Mi

  2. Center of Laboratory Technology and Experimental Medicine, China Medical University, North 2nd Road 92, Heping Ward, 110001, Shenyang, China

    Zeshi Cui

  3. Department of Pharmacology, Pharmaceutical College, China Medical University, North 2nd Road 92, Heping Ward, 110001, Shenyang, China

    Minjie Wei

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  1. Ailian Wang
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  2. Jian Wang
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  3. Huanyan Ren
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  4. Fan Yang
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  5. Lili Sun
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  6. Kexin Diao
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  7. Zhijuan Zhao
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  8. Min Song
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  9. Zeshi Cui
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  10. Enhua Wang
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  11. Minjie Wei
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  12. Xiaoyi Mi
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Correspondence to Xiaoyi Mi.

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Wang, A., Wang, J., Ren, H. et al. TRAF4 participates in Wnt/β-catenin signaling in breast cancer by upregulating β-catenin and mediating its translocation to the nucleus. Mol Cell Biochem 395, 211–219 (2014). https://doi.org/10.1007/s11010-014-2127-y

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  • DOI: https://doi.org/10.1007/s11010-014-2127-y

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