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Polymorphisms in glutathione S-transferase are risk factors for perioperative acute myocardial infarction after cardiac surgery: a preliminary study

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Abstract

In the present study we explored glutathione S-transferase (GST) polymorphisms in selected patients who experienced accelerated myocardial injury following open heart surgery and compared these to a control group of patients without postoperative complications. 758 Patients were enrolled from which 132 patients were selected to genotype analysis according to exclusion criteria. Patients were divided into the following groups: Group I: control patients (n = 78) without and Group II.: study patients (n = 54) with evidence of perioperative myocardial infarction. Genotyping for GSTP1 A (Ile105Ile/Ala113Ala), B (Ile105Val/Ala113Ala) and C (Ile105Val/Ala113Val) alleles was performed by using real-time-PCR. The heterozygous AC allele was nearly three times elevated (18.5 vs. 7.7 %) in the patients who suffered postoperative myocardial infarction compared to controls. Contrary, we found allele frequency of 14.1 % for homozygous BB allele in the control group whereas no such allele combination was present in the study group. These preliminary results may suggest the protective role for the B and C alleles during myocardial oxidative stress whereas the A allele may represent predisposing risk for cellular injury in patients undergoing cardiac surgery.

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Acknowledgments

This work was supported by the Hungarian Science Research Fund OTKA K78434 and the TÁMOP 4.2.2./B-10/1-2010-0029. The study was approved by TUKEB (3727.316-3255/2010).

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Authors and Affiliations

  1. Department of Surgical Research and Techniques, Medical Faculty, University of Pécs, 20 Kodály Z Street, Pecs, 7624, Hungary

    Viktória Kovacs, Borbala Balatonyi, Balazs Borsiczky, Gabor Jancso & Elisabeth Roth

  2. Department of Cardiac Surgery, Zala County Hospital, Zalaegerszeg, Hungary

    Balazs Gasz & Alotti Nasri

  3. Department of Medical Genetics, University of Pécs, Pecs, Hungary

    Luca Jaromi, Peter Kisfali & Bela Melegh

  4. Faculty of Medicine, Imperial College of London, London, UK

    Nandor Marczin

  5. Heart Institute, Medical Faculty, University of Pécs, Pecs, Hungary

    Sandor Szabados

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  1. Viktória Kovacs
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Correspondence to Elisabeth Roth.

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Kovacs, V., Gasz, B., Balatonyi, B. et al. Polymorphisms in glutathione S-transferase are risk factors for perioperative acute myocardial infarction after cardiac surgery: a preliminary study. Mol Cell Biochem 389, 79–84 (2014). https://doi.org/10.1007/s11010-013-1929-7

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  • DOI: https://doi.org/10.1007/s11010-013-1929-7

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